Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-06-02
1999-10-05
Low, Christopher S. F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 231, 536 235, 536 251, 536 253, 435 6, 435 691, 4353201, 435325, 435 911, 435 912, A61K 4800
Patent
active
059624256
ABSTRACT:
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
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Dagle John M.
Eder Paul S.
Walder Joseph A.
Walder Roxanne Y.
Low Christopher S. F.
Nguyen Dave Trong
University of Iowa Research Foundation
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