Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Destruction of hazardous or toxic waste
Patent
1998-04-17
2000-04-04
Beisner, William H.
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Destruction of hazardous or toxic waste
4352625, 210601, C12S 1300
Patent
active
060460458
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to two processes for the degradation of antimicrobially, in particular antibacterially, acting quinolone- and naphthyridonecarboxylic acids and derivatives thereof with the aid of wood rot fungi.
Antimicrobially acting substances are widely used in medicine and veterinary medicine. The preparation of these active compounds is accompanied by problems in the elimination of production residues, wastewaters and packaging containing the active compound. Wastewaters containing active compound from high-volume users, such as hospitals, animal breeders and animal fatteners, also present problems. Further problems may arise with the decontamination of waters or soils if active compound is undesirably released in the event of accidents.
In such cases, the antimicrobial activity of the active compounds can prevent the customary degradation by bacteria in soils, waters and sewage treatment plants. Under certain circumstances, an undesirable interference, for example in biologically operating sewage treatment plants, may even occur if relatively large quantities of wastewaters containing active compound have to be processed, i.e. in all these cases an expensive pretreatment of the wastewaters, residues and the like is necessary.
A simple treatment with which the active compounds can be degraded to the extent that they lose their antibiotic activity and their further degradation can take place by the customary biological degradation methods should be found for these cases.
Processes for the degradation of organic harmful substances with the aid of lignin-degrading fungi were known from a) German Offenlegungsschrift 4 104 624 and b) EP 0 192 237 A1.
However, the degradation in a) is demonstrated only on the example of aromatic hydrocarbons. According to German Offenlegungsschrift 4 104 624, halogen-containing hydrocarbons cannot be degraded in this manner.
EP 0 192 237 A1 mentions some examples of chlorinated hydrocarbons which can be degraded by the white rot fungus Phanerochaete chrysosporium.
It was not to be expected that the fluorine-containing heteroaromatic quinolones and naphthyridones are attacked by white rot fungi and, in particular, brown rot fungi or even wood-degrading Ascomycetes. In contrast there is the conviction, expressed publicly many times, that there are no microorganisms which can degrade such compounds (cf., for example, in the Swedish Journal "Land" June 1995, page 4). There is no indication in the scientific literature of a significant degradation of such compounds by microorganisms. Likewise, brown rot fungi generally are attributed only very limited capabilities in the cleavage of aromatic rings with furthermore significantly lower capacities (compared with white rot fungi; J. Buswell, 1991). In the abstracts of the "Division of Agrochemicals of the American Chemical Society 1993 issue No. 44", the extremely low bioavailability of .sup.14 C-labeled sarafloxacin in soil samples is reported in one abstract (No. 92). It was found that sarafloxacin was not notably degraded by microorganisms in the soil.
The present invention relates to:
1. A process for the treatment of antimicrobially, in particular antibacterially, acting quinolone- and naphthyridonecarboxylic acids and derivatives thereof with wood rot fungi, in particular white rot or brown rot fungi, if appropriate in the presence of water and/or inert solid or liquid substrates and further auxiliaries.
2. A process for the degradation of antibacterially and antimicrobially acting quinolone- and naphthyridonecarboxylic acids and derivatives thereof, characterized in that the active compounds are treated with wood rot fungi, in particular white or brown rot fungi, if appropriate in the presence of water and/or inert solid or liquid substances and further auxiliaries.
3. A process for the treatment of wastewaters which comprise antibacterially and antimicrobially acting quinolone- and naphthyridonecarboxylic acids and derivatives thereof with wood rot fungi, in particular white or brown rot fungi.
4. A process for
REFERENCES:
patent: 5143828 (1992-09-01), Atlas et al.
Karl Wolfgang
Martens Rainer
Rast Hans-Georg
Wetzstein Heinz-Georg
Zadrazil Frantisek
Akorli Godfried R.
Bayer Aktiengesellschaft
Beisner William H.
Gil Joseph C.
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