Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Reexamination Certificate
2011-01-18
2011-01-18
Steele, Amber D. (Department: 1639)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
C506S026000, C506S043000, C514S009100
Reexamination Certificate
active
07872096
ABSTRACT:
The invention provides methods and compositions for production of a cyclic polymer in a cell free system. In general, the methods of the invention involve ligating first and second recombinant intein domains to a linear synthetic polymer to form a compound containing the structure: D1-X(n)-D2, where D1is a first catalytic domain of an intein; D2is a second catalytic domain of an intein; where the second catalytic domain has at its N-terminus a first reactive site for the intein; and X(n)is a polymer of a number n of monomer X, where the polymer N-terminus has a second reactive site for the intein. D1-X(n)-D2compounds autocatalytically cyclize the X(n)polymer to produce a cyclic polymer. The invention finds use in a variety of drug discovery, clinical and therapeutic applications.
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Francis Carol L.
Gross Christopher M
Keddie James S.
Rigel Pharmaceuticals Inc.
Steele Amber D.
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