Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Reexamination Certificate
2006-11-14
2006-11-14
Gitomer, Ralph (Department: 1655)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
C424S094640, C530S368000
Reexamination Certificate
active
07135305
ABSTRACT:
Methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of lysis-inhibiting amounts of apolipoprotein E4, and methods for inhibiting lysis of coagulated blood and reducing risk of excessive lysis comprising administration of a specific level of a lysis-inhibiting agent wherein the specific level is based on the apolipoprotein phenotype of an individual, are provided. Methods for enhancing lysis of coagulated blood by administration of an Apo E peptide fragment to blood containing a clot lysis agent are also provided.
REFERENCES:
patent: 6046381 (2000-04-01), Mucke et al.
patent: 6313089 (2001-11-01), Matthew et al.
patent: 2004/0006017 (2004-01-01), Broderick et al.
Friedman G. et al. Apo E4 Genotype Prdicts a Poor Outcome in Survivors of Traumatic Brain Injury. Neurology 1999, vol. 52, pp. 244-248.
Shuvaev V., et al, Glycation of Apolipoprotein E Impairs Its Binding to Heparin: Identification of the Major Glycation Site. Biochimica et Biophysica Acta. Mar. 1999. vol. 1454, No. 3, pp. 296-308.
Broderick Joseph P.
Clark Joseph F.
Woo Daniel
Dinsmore & Shohl LLP
Everett Denise M.
Gitomer Ralph
LandOfFree
Methods for controlling the lysis of coagulated blood with... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for controlling the lysis of coagulated blood with..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for controlling the lysis of coagulated blood with... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3677440