Chemistry: molecular biology and microbiology – Condition responsive control process
Patent
1994-06-17
1995-10-17
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Condition responsive control process
435 4, 435 721, 435 694, 435 701, 435 703, 4352402, C12Q 300, C12Q 100, C12N 500, C12P 2100
Patent
active
054590310
ABSTRACT:
The invention relates to the effects of certain cell culture and/or production parameters on the carbohydrate composition of a cell culture-derived recombinant glycoprotein. The methods of the invention demonstrate a practical method for controlling levels of a sialic acid derivative, NGNA, in secreted recombinant glycoproteins which will be useful in a variety of bioprocessing systems.
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Derwent Abstract 87-151423 Otsuka Pharm KK J62258324 (Nov. 10, 1987).
Blumen Tracy K.
Grampp Gustavo E.
Hettwer David J.
Amgen Inc.
Crandall Craig A.
Lilling Herbert J.
Watt Stuart L.
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