Methods for controlling ocular hypertension with angiostatic ste

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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Details

514172, 514173, 514176, 514180, 514182, A61K 3156, A61K 3158

Patent

active

048762504

ABSTRACT:
Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical composition of the angiostatic steroids and methods for their use in treating ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed.

REFERENCES:
Knepper et al., Exp. Eye Res., 27,567-575 (1978) "Intraocular Pressure & Glycosaminoglycan Distribution in the Rabbit Eye: Effect of Age and Dexamethasone".
Hester et al., J. Ocular Pharmacology, vol. 3, No. 3, 185-189 (1987) "Steroid-Induced Ocular Hypertension in the Rabbit; A Model Using Subconjunctival Injections".
Crum et al., Science, vol. 230, 13/5-1378 (Dec., 1985) "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment".
Ingber et al., Endocrinology, vol. 119, No. 4, 1768-1775 (1986) "A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids:Induction of Capillary Basement Membrane Dissolution".
Southren et al., Invest. Uphth. & Vis. Science, vol. 28, 901-903 (1978) "Intraocular Hypotensive Effect of a Topically Applied Cortisol Metabolite:3.alpha.,5.beta.-Tetrahydrocortisol".
Folkman et al., Ann. Surg., vol. 206, No. 3,374-382 (1987) "Angiostatic Steroids".
Knepper et al., Pediatric Neuroscience, 12:240-251 (1985-86)"Glycosaminoglycans and Outflow Pathways of the Eye and Brain".
Johnson et al., Mayo Clin. Proc., 61:59-67 (1986 "Glaucoma: An Overview".
Rohen, Johanness W., Ophthalmology, vol. 90, No. 7,758-764 (1983) "Why is Intraocular Pressure Elevated in Chronic Simple Glaucoma?".
Knepper et al., Invest. Ophth & Vis. Science, vol. 26, 1093-1100 (Aug., 1985) "Effect of Dexamethasone, Progesterone, and Testosterone on IOP & GAGs in the Rabbit Eve".
Southren et al., Invest. Ophth & Vis. Science, vol. 26, 393-395 (Mar., 1985) "5.beta.-Dihydrocortisol: Possible Mediator of the Ocular Hypertension in Glaucoma".

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