Methods for controlling human endothelial cell proliferation and

Details Methods for controlling human endothelial cell proliferation and Methods for controlling human endothelial cell proliferation and

1989-04-10

1993-04-13

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Lymphokine

514 12, 424450, 424489, 530402, 530403, A61K 4500

Patent

active

052021165

ABSTRACT:
The present invention is directed to the use of a recently discovered cytokine, Oncostatin M, to control endothelial cell immunogenicity, fibrinolytic activity and proliferation, and to its use in the treatment of a variety of human vascular and immune system disorders involving the vascular endothelium. The method of the invention includes the use of mature, hybrid, modified or truncated forms of Oncostatin M as well as Oncostatin M analogs. The invention is described by way of examples in which the efficacy of such compounds is evaluated using various in vitro assay systems.

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