Methods for combinatorial synthesis on arrays

Details Methods for combinatorial synthesis on arrays Methods for combinatorial synthesis on arrays

2006-06-27

2011-11-01

Lundgren, Jeffrey S. (Department: 1629)

Combinatorial chemistry technology: method, library, apparatus

Method of creating a library

C506S007000, C506S013000, C435S006120

Reexamination Certificate

active

08048826

ABSTRACT:
The present invention provides methods for synthesizing arrays of polymers. The polymers are synthesized from monomers through a series of synthesis steps at chemically-modified electrodes by the action of an electrochemically generated reagent (EGR) at subsets of the electrodes. These subsets of electrodes vary with each step. Crosstalk of the EGR between electrodes is prevented by the production of a scavenging agent, which neutralizes the EGR, at those electrodes where the EGR is not produced. The scavenging agent acts as a “virtual cap” to prevent mis-incorporation of monomers and other anomalies in the polymers.

REFERENCES:
patent: 6093302 (2000-07-01), Montgomery
patent: 2004/0238369 (2004-12-01), Southern et al.

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