Methods for coating invasive devices with inhibitors of thrombin

Details Methods for coating invasive devices with inhibitors of thrombin Methods for coating invasive devices with inhibitors of thrombin

1995-05-11

1997-11-25

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 169, 514 13, 514 14, 530324, 530326, 530327, 623 11, A61K 3800

Patent

active

056913117

ABSTRACT:
This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association moiety (ABEAM); a linker portion of at least 18 .ANG. in length; and a thrombin catalytic site-directed moiety (CSDM). This invention also relates to compositions, combinations and methods which employ these molecules for therapeutic, prophylactic and diagnostic purposes.

REFERENCES:
patent: 5196404 (1993-03-01), Maraganore et al.
patent: 5433940 (1995-07-01), Maraganore et al.
Bajusz et al, Peptides, 1984, Almquist and Wiksell Intl., 473-476.
Chang, FEBS Lett. 164, pp. 307-313 (1983).
DiMaio et al, J. Biol. Chem. 265, pp. 21698-21703 (1990).
Kettner et al, Thromb. Res. 14, pp. 969-973 (1979).
Maraganore et al, J. Biol. Chem. 264, pp. 8692-8698 (1989).
Markwardt, Noov. Rev. Fr. Hematol. 30, pp. 161-165 (1988).
Rauber and Shaw, Analytical Biochem. 168, 259-264 (1988).
Dodt et al, FEBS Lett. 165, 180-184 (1984).

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