Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-05-16
2010-10-26
Cook, Lisa V (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C436S501000, C436S518000, C422S050000, C422S067000, C424S009100
Reexamination Certificate
active
07820399
ABSTRACT:
The present invention provides methods for isolating and characterizing the glycosylation sites of a glycoprotein, such as a glycosylated antibody. In particular, the methods employ affinity capture, liquid chromatography, and mass spectrometry to determine, for example, the location of the glycopeptide, the heterogeneity of the glycan attached to the glycopeptide, the mass of the glycopeptide, and/or the peptide sequence.
REFERENCES:
patent: 07083922 (1995-03-01), None
Mathov et al. (Molecular Immunology, vol. 32, No. 14/15, pp. 1123-1130, 1995).
Srinivasan Mohan
Wu Zhigang
Cook Lisa V
DiGiorgio, Esq. Jeanne M.
Lahive & Cockfield LLP
Medarex Inc.
Remillard, Esq. Jane E.
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