Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-05-11
1985-09-17
Love, Ethel G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3136
Patent
active
045421536
ABSTRACT:
2-alkyl-5,6 alkylenedioxyindenes and indane-1-di- or tri- alkylammonium salts are useful as calcium antagonists, for example in arrhythmia. The compounds are prepared from the known corresponding 2,5,6-substituted indene-1-1dimethylammonium salts by alkylation and/or hydrogenation.
REFERENCES:
patent: 2541967 (1951-02-01), Kolloff et al.
patent: 2916490 (1959-12-01), Schenck et al.
patent: 3201470 (1965-08-01), Heubner
patent: 3253037 (1966-05-01), Huebner
D. T. Witiak, D. R. Williams, S. V. Kakodkar, C. Hite & M. S. Chen, J. Org. Chem., 39, 1242 (1974).
R. G. Rahwan, M. M. Faust & D. T. Witiak, J. Pharmacol. Exp. Ther. 201, 126 (1977).
M. F. Piascik, R. G. Rahway & D. T. Witiak, J. Pharmacol. Exp. Ther., 205, 155 (1978).
D. T. Witiak, S. V. Kakodkar, T. P. Johnson, J. R. Baldwin & R. G. Rahway, J. Med. Chem., 22, 77 (1979).
C. E. Akesson, R. G. Rahway, D. T. Witiak, R. J. Brumbaugh, Res. Commun Chem. Pathol, Pharmacol. 27, 265, (1980).
M. F. Piascik, R. G. Rahwan & D. T. Witiak, J. Pharmacol, Exp. Ther., 210, 141 (1979).
M. F. Piascik, M. T. Piascik, D. T. Witiak & R. G. Rahway, Canad J. Physiol. Pharmacol., 57, 1350 (1979).
J. L. Lynch, R. G. Rahway, & D. T. Witiak, J. Card. Pharmcol. 60, 49 (1981).
Rahwan Ralf G.
Witiak Donald T.
Love Ethel G.
Millard Sidney W.
The Ohio State University Research Foundation
LandOfFree
Methods for changing calcium metabolism within the cells of a ma does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for changing calcium metabolism within the cells of a ma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for changing calcium metabolism within the cells of a ma will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-370429