Methods for cell-based combinatorial logic

Details Methods for cell-based combinatorial logic Methods for cell-based combinatorial logic

2006-03-28

2006-03-28

Zeman, Mark K. (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C703S011000, C435S003000, C435S030000, C435S173100, C435S182000

Reexamination Certificate

active

07020560

ABSTRACT:
A method for cell-based combinatorial logic includes the steps of providing at least one genetically engineered cell, the genetically engineered cell having at least one transcriptional unit. The transcriptional unit includes a gene and a promoter, wherein application of a stimulus to the promoter results in the expression of a gene product. An energetic or chemical stimulus is applied to activate the promoter, wherein the detection of an output signal corresponds to the presence of a gene product. The cell can include a plurality of transcriptional units configured to form logic gates. The logic gates of a plurality of cells can be operably interconnected by release of output signals, such as chemical stimuli.

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