Methods for carbon isotope labeling synthesis of ketones and...

Details Methods for carbon isotope labeling synthesis of ketones and... Methods for carbon isotope labeling synthesis of ketones and...

2004-12-20

2011-12-13

Hartley, Michael G (Department: 1618)

Organic compounds -- part of the class 532-570 series

Organic compounds

Radioactive metal containing

C204S001001, C422S169000, C422S186000

Reexamination Certificate

active

08076464

ABSTRACT:
Methods and reagents for synthesizing carbon-isotope labeled ketones and amines by carbonylation via Suzuki coupling reaction using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled ketones and amines are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.

REFERENCES:
patent: WO-02/102711 (2002-12-01), None
S.K. Zeisler et al Conversion of No-Carrier-added [11C] carbon dioxide to [11C] carbon monoxide on Molybdenum for the synthesis of 11C-labeleled aromatic ketones, Appl. Radiat, Isot, vol. 48 (8), 1091-1095, 1997.
Pelle Lidstrom et al. [11C]Carbon monoxide in the palladium-mediated synthesis of 11C-labelled ketones, J. Chem. Soc. Perkin. Trans. 1, 2701, 1997.
S.K. Zeisler, et.al., “Conversion of No-Carrier Added 11C Carbon Dioxide to 11C Carbon Monoxide on Molybdenum for the Synthesis of 11C-Labelled Aromatic Ketones” Appl. Radiat. Isot., vol. 48, No. 8, 1997 pp. 1091-1095.
Cecile Perrio-Huard, et.al., “Reductive Aminationof Carboxylic Acids and 11C Magnesium Halide Carboxylates” J. Chem. Soc. Perkin Trans. 1 2000, pp. 311-316.
Pelle Lidstrom, et.al., 11C Carbon Monoxide in the Palladium-Mediated Synthesis of 11C-Labelled Ketones J. Chem. Soc., Perkin Trans. 1, 1997 pp. 2701-2706.
PCT/IB2004/004199 Int'l Search Report and Written Opinion dated May 2005.

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