Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-01-25
1998-07-07
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514 2, 514 6, 514 8, 514 28, 514 32, 514 43, 514 44, 514 81, 514245, 514386, 514410, 514517, 514564, 514567, 514589, 514590, A61K 3140
Patent
active
057769257
ABSTRACT:
Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be P-glycoprotein-independent since texaphyrins are effective in both a P-glycoprotein-expressing and a P-glycoprotein -nonexpressing cell line. Methods are provided for the treatment of cancers such as leukemia, lymphoma, carcinoma, and sarcoma using a texaphyrin as a chemosensitizer.
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Physician's Desk Refe
Miller Richard A.
Young Stuart W.
Pharmacyclics Inc.
Raymond Richard L.
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