Methods for blocking the expression of specifically targeted gen

Details Methods for blocking the expression of specifically targeted gen Methods for blocking the expression of specifically targeted gen

1991-03-19

1996-02-13

Low, Christopher S. F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 221, 536 231, 536 241, 536 2431, 536 2433, 536 254, 435 6, 435 691, 436501, A01N 4334, C07H 1512, A61K 31395

Patent

active

054911338

ABSTRACT:
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.

REFERENCES:
Dagle et al. (1991) Antisense Research and Development, vol. 1, pp. 11-20.
Minshull et al. (1986) Nucleic Acids Res., vol. 14, No. 16, pp. 6433-6451.
Eckestein (1983) Angewandte Chemie, vol. 22, No. 6, pp. 423-439.
Marcus-Sekura, C. J. et al., 1987, Nucleic Acids Res. 15:5749-5763.

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