Methods for augmenting immunological responses through the admin

Details Methods for augmenting immunological responses through the admin Methods for augmenting immunological responses through the admin

1994-09-21

1999-07-06

Adams, Donald E.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

4241841, 514177, 514178, 514182, A61K 4500, A61K 3900, A61K 3156

Patent

active

059194650

ABSTRACT:
Methods for augmenting immune responses in immunodeficient individuals are disclosed. The methods utilize steroid hormones, particularly DHEA, its prohormones (particularly DHEA-S), and DHEA-cogeners. Additional embodiments of the invention include pharmaceutical compositions for use in the methods.

REFERENCES:
patent: 4080448 (1978-03-01), Mirsky
patent: 4110446 (1978-08-01), DeLuca et al.
patent: 4341774 (1982-07-01), Aoki et al.
patent: 4496556 (1985-01-01), Orentreich et al.
patent: 4507289 (1985-03-01), Coleman et al.
patent: 4518595 (1985-05-01), Coleman et al.
patent: 4542129 (1985-09-01), Orentreich
patent: 4602008 (1986-07-01), Krsek
patent: 4617299 (1986-10-01), Knepper
patent: 4628052 (1986-12-01), Peat
patent: 4666898 (1987-05-01), Coleman et al.
patent: 4778750 (1988-10-01), Gottlieb
patent: 4789658 (1988-12-01), Yoshimoto et al.
patent: 4898694 (1990-02-01), Schwartz et al.
patent: 4956355 (1990-09-01), Prendergast
patent: 4963367 (1990-10-01), Ecanow
patent: 4980358 (1990-12-01), Smith
patent: 5000956 (1991-03-01), Amkraut et al.
patent: 5007284 (1991-12-01), Loria et al.
patent: 5077284 (1991-12-01), Loria et al.
patent: 5206008 (1993-04-01), Loria
Callard and Turner, 1990, Immunol. Today 11:200-203.
Levy, J., 1993, Microbiol. Rev. 57:224-226.
Cooper and Lawton, 1991, "Disorders of the Immune System" in Harrison's Principles of Internal Medicine, Wilson et al. eds., McGraw-Hill, New York, pp. 1395-1402.
Kovacs et al., 1995, New Engl. J. Med. 332:567-575.
Lawrence et al., 1992, Vet. Immunol. Immunopathol. 35:51-9.
Adkins et al., 1993, J. Immunol. 151:6617-26.
Lynn and Wong, 1995, FASEB J. 9:1147-56.
Barbouche et al., 1992, Scand. J. Immunol. 35:659-667.
Khansari et al., 1990, Effects of Stress on the Immune System, Immunol. Today, 11:170-175.
Dolecek, R., 1989, Endocrine Changes after Burn Trauma-A Review, Keio. J. Med., 38:262-276.
Lephart et al., 1987, Effect of Burn Trauma on Adrenal and Testicular Steroid Hormone Production, J. Clin. Endocrinol. Metab. 64:842-848.
Loria et al., "Protection Against Acute Lethal Viral Infections With the Native Steroid Dehydroepiandrosterone (DHEA)" Journal of Medical Virology (1988) 26:301-314.
Ben-Nathan, D. et al. (1992). "Dehydroepiandrosterone Protects Mice Inoculated with West Nile Virus and Exposed to Cold Stress," J. Med. Virol. 38:159-166.
Araneo, B. et al. (1991). "Dihydrotestosterone Exerts a Depressive Influence on the Production of Interleukin-4 (IL-4), IL-5 and .gamma.-Interferon, but not IL-2 by Activated Murine T Cells," Blood 78:3, pp. 688-699.
Meikle, A. et al. (1991). "Adrenal Androgen Secretion and Biologic Effects," Endocrinol. Metab. Clin. N. Am. 29:2, pp. 381-400.
Suzuki, T. et al. (1991). "Dehydroepiandrosterone Enhances IL2 Production and Cytotoxic Effector Function of Human T Cells," Clin. Immunol. Immunopathol. 61:202-211.
Wiedmeier, S. et al. (1991). "Thymic Modulation of IL-2 and IL-4 Synthesis by Peripheral T Cells," Cell. Immunol. 135:501-518.
Wu, C.Y. et al. (1991). "Glucocorticoids Supress the Production of Interleukin 4 by Human Lymphocytes," Eur. J. Immunol. 21:2645-2647.
Daynes, R. et al. (1991). "Locally Active Steroid Hormones may Facilitate Compartmentalization of Immunity by Regulating the Tyes of Lymphokines Produced by Helper T Cells," Res. Immunol. 142:40-45.
van der Heliden, P. et al. (1991). "Manipulation of Intestinal Immune Responses Against Ovalbumin by Cholera Toxin and its B Subunit in Mice," Immunol. 72:89-93.
Lemire, J. et al. (1991). "1,25-Dihydroxyvitamin D.sub.3 Prevents the In Vivo Induction of Murine Experimental Autoimmune Encephalomyelitis," J. Clin. Invest. 87:1103-1107.
Finkelman, R. et al. (1991). "Vitamin D Deficiency Causes a Selective Reduction in Deposition of Transforming Growth Factor .beta. in Rat Bone: Possible Mechanism for Impaired Osteoinduction," Proc. Natl. Acad. Sci. USA 88:3657-3660.
Daynes, R. et al. (1990). "Regulation of Murine Lymphokine Production In Vivo: II. Dehydroepiandrosterone is a Natural Enhancer of Interleukin 2 Synthesis by Helper T Cells," Eur. J. Immunol. 20:4, pp. 793-802.
Daynes, R. et al. (1990). "Regulation of Murine Lymphokine Production In Vivo: III. The Lymphoid Tissue Microenvironment Exerts Regulatory Influences over T Helper Cell Function," J. Exp. Med. 171:979-9961.
Finkelman, F. et al. (1990). "Lymphokine Control of In Vivo Immunoglobulin Isotype Selection," Ann. Rev. Immunol. 8:303-333.
Mbawuike, I. et al. (1990). "Enhancement of the Protective Efficacy of Inactivated Influenza A Virus Vaccine in Aged Mice by IL-2 Liposomes," Vaccine 8:347-352.
Risdon, G. et al. (1990). Mechanisms of Chemoprevention by Dietary Dehydroisoandrosterone: Inhibition of Lymphopoiesis,: Am. J. Pathol. 136:4, pp. 759-769.
May, M. et al. (1990). "Protection from Glucocorticoid Induced Thymic Involution by Dehydroepiandrosterone," Life Sciences 46:1627-1631.
Ledman, D. et al. (1990). "Mechanism for Transforming Growth Factor .beta. and IL-2 Enhancement of IgA Expression in Lipopolysaccharide-Stimulated B Cell Cultures," J. Immunol. 144:952-959.
Brown, S. et al. (1990). "Neuroendocrine Immune Interactions," Immunophysiology: The Role of Cells and Cytokines in Immunity and Inflammation, J. Oppenheim, Eds., Oxford University Press, N.Y., pp. 306-319.
Wira, C.R. et al. (1990). "Glucocorticoid Regulation of the Humoral Immune System I: In vivo Effects of Dexamethasone on IgA and IgG in Serum and at
Matsunaga, A. et al., (1989). "Dehydroisoandrosterone Prevention of Autoimmune Disease in NZB/W F1 Mice: Lack of an Effect on Associated Immunological Abnor-malities," Biochim. Biophys. Acta 992:3, pp. 265-271.
Abe, J. et al. (1989). "A Synthetic Analogue of Vitamin D.sub.3, 22-Oxa-1.alpha., 25-Dihyroxy-Vitamin D.sub.3, is a Potent Modulator of In Vivo Immunoregulating Activity Without Inducing Hypercalcemia in Mice," Endocrinol. 124:5, pp. 2645-2647.
Bhalla, A.K. (1989). "Hormones and the Immune Response," Ann. Rheum. Dis. 48:1-6.
Coffman, R. et al. (1989). "T-Helper Heterogeneity and Immune Response Patterns," Hosp. Pract., Aug. 15, 1989, pp. 101-133.
Daynes. R. et al. (1989). "Contrasting Effects of Glucocorticoids on the Capacity of T Cells to Produce the Growth Factors Interleukin 2 and Interleukin 4," Eur. J. Immunol. 19:2319-2325.
Rogers, W. et al. (1989). "Dehydroepiandrosterone Protection Against Dexamethasone Induced Thymic Involution: Flowcytometric and Mechanistic Studies," The Endocrine Society: Program & Abstracts, No. 668, p. 189
Dolecek, R. (1989). "Endocrine Changes After Burn Trauma--A Review," Keio J. Med. 38:3 pp. 262-276.
Rigby, W. (1988) "The Immunobiology of Vitamin D," Immunol. Today 9:2, pp. 54-57. DHEA Binding in Rat Liver," Biochem. Biophys. Res. Communicats. 156:1, pp. 22-29.
Regelson, W. et al. (1988). "Hormonal Intervention: Buffer Hormones or State Dependency: The Role of Dehydroepiandrosterone (DHEA), Thyroid Hormone, Estro-gen and Hypophysectomy in Aging," Ann. N.Y. Acad. Sci. 518:260-273.
Boger, J. et al. (1988). "Immodulatory Approaches to the Treatment of Inflammation," Ann. Reps. Med. Chem. 23:171-180.
Dinarello, C. et al. (1987). "Current Concepts: Lymphokines," N. Eng. J. Med. 317:15, pp. 940-945.
Mestecky, J. (1987). "The Common Mucosal Immune System and Current Strategies for Induction of Immune Responses in External Secretions," J. Clin. Immunol. 7:4, pp. 265-276.
Petkovich, P. et al. (1987). "1,25-Dihydroxyvitamin D.sub.3 Increases Epidermal Growth Factor Receptors and Transforming Growth Factor .beta.-Like Activity in a Bone-Derived Cell Line," J. Biol. Chem. 262:28, pp. 13424-13428.
Pfeilschifter, J. et al. (1987). "Modulation of Type .beta. Transforming Growth Factor Activity in Bone Cultures by Osteotropic Hormones," Proc. Nat. Acad. Sci. USA 84:2024-2028.
Matsushima, K. et al. (1987). "Phosphorylation of a Cytosolic 65-kDa Protein Induced by Interleukin 1 in Glucocorticoid Pretreated Normal Human Peripheral Blood Mono-nuclear Leukocytes," J. Immunol. 1393367-3374.
Knabbe, C. et al. (1987). "Evidence That Transforming Growth Factor-.beta. is a Hormonally Regulated Negative Growth Factor in Human Breast Cancer Ce

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