Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2006-04-04
2006-04-04
Ketter, James (Department: 1636)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C435S458000, C435S472000
Reexamination Certificate
active
07022336
ABSTRACT:
The invention provides methods of attaching proteins to lipidic microparticles with efficiencies of at least 77%. The proteins are attached to linker molecules comprising a hydrophilic domain and a hydrophobic domain. The proteins can be antibodies, antibody fragments, hormones, growth factors, enzymes, or nucleic acid binding proteins, or other proteins. The proteins can be chemically conjugated to the linker molecules, or they can be fused to the linker molecules by recombinant techniques.
REFERENCES:
patent: 5459127 (1995-10-01), Felgner et al.
patent: 5527528 (1996-06-01), Allen et al.
patent: 5681940 (1997-10-01), Wang et al.
patent: 5783210 (1998-07-01), Tremblay et al.
patent: 5891468 (1999-04-01), Martin et al.
patent: 6056973 (2000-05-01), Allen et al.
patent: 6210707 (2001-04-01), Papahadjopoulos et al.
patent: 6316024 (2001-11-01), Allen et al.
patent: 6528087 (2003-03-01), Papahadjopoulos et al.
patent: WO 98/16202 (1998-04-01), None
patent: WO 98/02454 (1998-07-01), None
Zalipsky et al., “Poly(ethylene glycol)-Grafted Liposomes with Oligopeptide or Oligosaccharide Ligands Appended to the Termini of the Polymer Chains,”Bioconjugate Chem., 8:111-118 (1997).
Blaese, et al., “Vectors in Cancer Therapy: How Will They Deliver?”Cancer Gene Therapy, 2(4):291-197 (1995).
Crystal et al., “Transfer of Genes of Humans: Early Lessons and Obstacles to Success,”Science270:404-410 (1995).
Gao et al., “Cationic Liposome-Miediated Gene Transfer,”Gene Therapy, 2:710-722 (1995).
Behr, “Gene Transfer With Synthetic Cationic Amphiphiles: Prospects for Gene Therapy,”Bioconjugate Chem., 5:382-389 (1994).
Remy et al., “Gene Transfer With a Series of Lipophilic DNA-Binding Molecules,”Bioconjugate Chem., 5:647-654 (1994).
Plum et al., “Condensation of DNA by Trivalent Cations. 2 Effects of Cation Structure,”Biopolymers, 30:631-643 (1990).
Allen et al., “Liposomes Containing Synthetic Lipid Derivatives of Poly(Ethylene Glyocol) Show Prolonged Circulation Half-Lives In Vivo,”Biochimica et Biophysica Acia.1066:29-36 (1991).
Papahadjopoulos et al., “Sterically Stabilized Liposomes: Improvements in Pharmacokinetics and Antitumor Therapeutic Efficacy, ”Proc. Nat'l Acad. Sci USA, 88:11460-11464 (1991).
Ahmad et al., “Antibody-Mediated Specific Binding and Cytotoxicity of Liposome-Entrapped Doxorubicin to Lung Cancer Cells in Vitro,”Cancer Research, 52:4817-4820 (1992).
Martin et al, “Irreversible Coupling of Immunoglobulin Fragments to Performed Vesicles,”J. of Biological Chemistry, 257(1):286-288 (1982).
Szoka Jr. et al., “Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse-Phase Evaporation,”Proc. Nat'l. Acad. Sci. USA, 75(9):4194-4196 (1978).
Felgner et al., “Lipofection: A High Efficient, Lipid-Mediated Dan-Transfection Procedure,”Proc. Nat'l. Acad. Sci. USA, 84:7413-7417 (1987).
Felgner et al., “Enhanced Gene Delivery and Mechanism Studies With a Novel Series of Cationic Lipid Formulations,”J. Biological Chemistry, 269(4):2550-2561 (1994).
Liu et al., “Cationic Liposome-Mediated Intravenous Gene Delivery, ”J. Biological Chemistry, 270(42):24864-24870 (1995).
Mayhew et al., “Role of Cholesterol in Enhancing the Antitumore Activity of Cytosine Arabinoside Entrapped in Liposomes,”Cancer Treatment Reports, 63(11-12):1923-1928 (1979).
Zhu et al., “Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice,”Science, 26:209-211 (1993).
Solodin et al., “A Novel Series of Amphiphilic Imidazolinium Compounds for In Vitro and In Vivo Gene Delivery,”Biochemistry, 34:13537-12544 (1995).
Thierry et al., “Systematic Gene Therapy: Biodistribution and Long-Term Expression of a Transgene in Mice,”Proc. Nat'l. Acad. Sci. USA, 92:9741-9746 (1995).
Carter et al., “High LevelEscherichia ColiExpression and Production of a Bivalent Humanized Antibody Fragment,”Biotechnology, 10:163-167 (1992).
Hofland et al., “Formation of Stable Cationic Lipid/DNA Complexes For Gene Transfer,”Proc. Nat'l. Acad. Sci. USA, 93:7305-7309 (1996).
Hansen et al., “Attachment of antibodies to sterically stabilized liposomes: Evaluation, comparison and optimization of coupling procedures,” Biochimica et biophysica Acta, 1239:133-144 (1995).
Hong Keelung
Kirpotin Dmitri B.
Papahadjopoulos Demetrios
Zheng Weiwen
Ketter James
The Regents of the University of California
Townsend and Townsend / and Crew LLP
LandOfFree
Methods for attaching proteins to lipidic microparticles... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for attaching proteins to lipidic microparticles..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for attaching proteins to lipidic microparticles... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3560708