Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1996-09-17
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
436501, 436 63, 536 2431, 536 2433, 935 77, 935 78, 935 34, 435 911, C12Q 168, C12P 1934, C07H 2104
Patent
active
055567541
ABSTRACT:
The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. The methods of treatment involve the use of drugs capable of suppressing expression of MHC Class I molecules. In particular the use of the drug methimazole to suppress expression of MHC Class I molecules in the treatment of autoimmune diseases and the prevention or treatment of rejection in a transplant recipient is disclosed. In addition in vivo and in vitro assays are provided for the assessment and development of drugs capable of suppressing MHC Class I molecules.
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Kohn Leonard
Ledley Fred D.
Mozes Edna
Napolitano Giorgio
Saji Motoyasu
Jones W. Gary
Myers Carla
The United States of America as represented by the Department of
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