Methods for assessing efficacy of chemotherapeutic agents

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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C536S023100, C536S024300

Reexamination Certificate

active

08039213

ABSTRACT:
Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide insight into the in vivo effectiveness of a therapeutic, and lead to more effective chemotherapeutic treatment.

REFERENCES:
patent: 4423145 (1983-12-01), Stampfer et al.
patent: 4559299 (1985-12-01), Rotman
patent: 4668618 (1987-05-01), Thornthwaite
patent: 4816395 (1989-03-01), Hancock et al.
patent: 4937187 (1990-06-01), Rotman
patent: 4996145 (1991-02-01), Weisenthal
patent: 5242806 (1993-09-01), Yen-Maguire et al.
patent: 5270172 (1993-12-01), Morgan
patent: 5403574 (1995-04-01), Piwnica-Worms
patent: 5443950 (1995-08-01), Naughton et al.
patent: 5607918 (1997-03-01), Eriksson et al.
patent: 5705270 (1998-01-01), Soon-Shiong et al.
patent: 5728541 (1998-03-01), Kornblith
patent: 5789158 (1998-08-01), Knowles et al.
patent: 5874218 (1999-02-01), Drolet et al.
patent: 5888765 (1999-03-01), Patterson et al.
patent: 5942385 (1999-08-01), Hirth
patent: 5972639 (1999-10-01), Parandoosh
patent: 6008007 (1999-12-01), Fruehauf et al.
patent: 6020473 (2000-02-01), Keyt et al.
patent: 6111092 (2000-08-01), Williamson
patent: 6261795 (2001-07-01), Fruehauf et al.
patent: 6303324 (2001-10-01), Fruehauf
patent: 6335170 (2002-01-01), Orntoft
patent: 6416967 (2002-07-01), Kornblith
patent: 6511806 (2003-01-01), Fruehauf et al.
patent: 6664062 (2003-12-01), Stanton, Jr.
patent: 6887680 (2005-05-01), Kornblith
patent: 6900027 (2005-05-01), Kornblith
patent: 6933129 (2005-08-01), Kornblith
patent: 7112415 (2006-09-01), Kornblith
patent: 7314731 (2008-01-01), Kornblith
patent: 7563593 (2009-07-01), Kornblith
patent: 7829288 (2010-11-01), Kornblith et al.
patent: 2002/0168679 (2002-11-01), Naus et al.
patent: 2002/0192638 (2002-12-01), Kornblith
patent: 2003/0096290 (2003-05-01), Fruehauf et al.
patent: 2004/0023375 (2004-02-01), Kornblith et al.
patent: 2004/0072722 (2004-04-01), Kornblith et al.
patent: 2004/0086888 (2004-05-01), Kornblith et al.
patent: 2007/0059821 (2007-03-01), Kornblith et al.
patent: 2008/0085519 (2008-04-01), Gabrin et al.
patent: 0911389 (1999-04-01), None
patent: WO 96/10742 (1996-04-01), None
patent: WO 98/02038 (1998-01-01), None
patent: WO 98/02038 (1998-01-01), None
patent: WO 00/75287 (2000-12-01), None
patent: WO 01/65994 (2001-09-01), None
patent: WO 01/79540 (2001-10-01), None
patent: WO 02/33117 (2002-04-01), None
patent: WO 2004/015065 (2004-02-01), None
patent: WO 2004/035833 (2004-04-01), None
patent: WO 2004/035833 (2004-04-01), None
Abstract for JP 2003-199585, Database WPI Week 200377, Jul. 15, 2003, XP002450791.
Supplementary European Search Report based on International Application No. PCT/US2003/032285, (Oct. 8, 2007).
PL Kornblith et al., “Response variability of human brain tumors to AZQ in tissue cultures”. Journal of Neuro-Oncology, 1986, pp. 49-54, vol. 4, Martinus Nijhoff Publishers, Boston.
RS Weinstein et al., “Ultrastructure of a cloned astrocytoma in tissue cultures,” Cancer, 1971, pp. 1174-1181, vol. 27.
PMoL Black et al., “Ultrastructural and electrophysiological features of maningloma whoris in tissue culture,” Acta Neuropathol (Ber). 1979, vol. 46, pp. 33-38.
RM Scott et al., “Invasiveness in tissue culture: A technique for study of gliomas,” Surg Forum, 1978, pp. 531-533, vol. 29.
T. Liszczak et al., “Morphological, biochemical, ultrastructural, tissue culture and clinical observations of typical and aggressive craniopharyngiomas,” Acta Neuropathol (Berl), 1978, pp. 191-203, vol. 43.
PL Kornblith et al., “Growth-inhibitory effects of diphenythydantoin on human brain tumor cells in culture,” Neurosurgery, 1978, pp. 122-127, vol. 2.
RR Weichselbaum et al., “Characterization and radiobiologic parameters of medulloblastoma in vitro,” Cancer, 1977, pp. 1087-1096, vol. 40.
RL Martuza et al., “Characteristics of human optic gilomas in tissue culture,” J. Neurosurg, 1977, pp. 78-84, vol. 46.
MA Oberc-Greenwood, et al., “Ultrastructural features of the lymphocyte-stimulated halos produced by human glloma-derived cells in vitro,” Journal of Neuro-Oncology, 1986, pp. 387-396, vol. 3.
BH Smith et al., “Membrane and cytoplasmic changes in 1,3-bis (2-chloroathy 1)-1-nitrosource (8CND)-sensitive and resistant human malignant glloma-derived cell lines” Journal of Neuro-Oncology, 1983, pp. 237-248, vol. 1.
GA Curt et al., “Phase II and pharmacokinetic study of aziridinyl-benzoquinoria (2,5-diaziridinyl-3,6-bis(carboethoxyaminc)-1,4 benzoquinone, diaziquone, NSC 182986) in high grade gllomas,” Cancer Research, 1983, pp. 6102-6105, vol. 43, Issue 12 pt. 1.
N Shitara et al., “Flowcytomeric and cytogenetic analysis of human cultured cell lines derived from high- and low-grades astrocytomas,” Acta Neuropathol (Berl), 1983, pp. 40-46, vol. 60.
MK Gumerlock et al., “Chemical differeniiation of cultured human giloma cells: Morphologic and Immunologic effects,” Surgical Forum, 1981, pp. 475-477, vol. XXXII.
PL Kornblith et al., “Growth-inhibitory effect of diphenythydantoin on murine astrocytornas,” Neurosurgery, 1979, pp. 259-263, vol. 5.
MC Trachtenberg et al., “Biophysical properties of cultured human gliaf cells,” Brain Research, 1972, pp. 279-298, vol. 38.
J. Lightbody et al., “Biochemically differentiated clonal human glial cells in tissue culture,” J. Neurobiology, 1970, pp. 411-417, vol. 1, No. 4.
PMcL Black et al., “Biophysical properties of human astrocytic brain tumor cells in cell nature,” Journal of Cellular Physiology, 1980, pp. 565-570, vol. 105.
TM Liszczak et al., “Ultrastructure of human endometrial epitheiium in monolayer culture with and without steroid hormones,” In Vitro, 1977, pp. 344-356, vol. 13, No. 6.
TM Liszozak et al., “Procedure for the embedmeril and ultrastructural visualization of cells cultured on plastic microfest plates,” Journal of Immunological Methods, 1977, pp. 131-134, vol. 15.
RM Stewart et al., “Glutamate accumulation by human gliomas and meningiomas in tissue culture” Brain Research, 1976, pp. 441-452, vol. 118.
PL Kornblith et al., “The future of therapy for globlastorna,” Surg Neurol, 1993, pp. 536-543, vol. 39.
PL Kornblith, “Management of mailgnant gliomas,” Neurosurgery Quarterly, 1991, pp. 97-110, vol. 1, Issue 2.
PL Kornblith et al., “Chemotherapy for malignant gllomas,” Journal of Neurosurgery, 1986, pp. 1-17, vol. 68, Issue 1.
PE McKeever et al., “Products of cells cultured from gllomas: VI. Immunofluorescent, morphometric, and ultrastructural characterization of two different cell types growing from explants of human gliomas,” American Journal of Pathology, 1987. pp. 356-372, vol. 127, Issue 2.
PmCL Black et al., “Immunological, biological, ultrastructural, and electrophysiological characteristics of a human glioblastoma-derived cell culture line,” J. Neurosurg, 1982, pp. 62-72, vol. 56.
PL Kornblith, “The role of cylotoxic chemotherapy in the treatment of malignant brain tumors,” Surg Neurol, 1995, pp. 551-552, vol. 44.
WC Welch et al., “Morphologic immunologic, biochemical and cytogenetic characteristics of the human glioblastoma-derived cell line, SNB-19,” Journal of the Society for In Vitro Biology, 1995, pp. 610-616, vol. 31.
E Sariban et al., “DNA crosslinking response of human malignant glioma cell strains to chloroethytrillrosoureas. cisplatin and diaziquone.” Cancer Research, 1987, pp. 3988-3994, vol. 47, Issue 15.
Alley, M., “Morphometric and Colorímetríc Analyses of Human Tumor Cell Line Growth and Drug Sensitivity in Soft Agar Culture,”

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