Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1997-04-04
1999-12-07
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
514255, 514560, A61K 3159
Patent
active
059983930
ABSTRACT:
Described are in vivo methods for testing the activity of vitamin D.sub.3 (1,25-dihydroxyvitamin D.sub.3) and analogs thereof in human skin and for testing the effect of a test compound on said activity. Also described are methods for enhancing the in vivo activity of vitamin D.sub.3 and analogs thereof by coadministering vitamin D.sub.3 or an analog thereof with an RXR ligand, a 24-hydroxylase inhibitor, or a mixture thereof. Preferred RXR ligand materials are retinoids, such as 9-cis retinoic acid, and precursors thereof, such as all trans retinoic acid. Preferred 24-hydroxylase inhibitors are imidazoles, especially those inhibiting cytochrome-P450 oxidative enzymes, such as ketoconazole. Also included is a method for determining whether a candidate compound inhibits 24-hydroxylase activity or induction thereof.
REFERENCES:
patent: 4569935 (1986-02-01), Rosenberg et al.
Spearman et al., Brit. J. Dermatol., 90(5), 553-60 (Abstract), 1974.
Lutzow-Holm et al. Experimental Dermatology, 2(3) 113-20 (Denmark) (Abstract), 1993.
Cauwenbergh Geert
Kang Sewon
Voorhees John J.
LandOfFree
Methods for assessing 1,25(OH).sub.2 D.sub.3 activity in skin an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for assessing 1,25(OH).sub.2 D.sub.3 activity in skin an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for assessing 1,25(OH).sub.2 D.sub.3 activity in skin an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-823915