Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-07-05
2005-07-05
Smith, Lynette R. F. (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C435S005000, C435S007200, C435S007400, C435S007600, C435S007710, C435S007720, C435S007910, C435S007100, C435S183000, C435S220000
Reexamination Certificate
active
06913895
ABSTRACT:
This invention relates to the field of bacterial transglycosylase reactions. The invention is directed to methods for assaying for transglycosylase activity, methods of identifying inhibitors of transglycosylase activity, inhibitors identified by such methods, and methods of identifying the stage of inhibition at which such inhibitors act.
REFERENCES:
patent: 4687732 (1987-08-01), Ward et al.
patent: 5681694 (1997-10-01), Hoskins et al.
Allen, N. E. et al., “Molecular interactions of a semisynthetic glycopeptide antibiotic with D-alanyl-D-alanine and D-alanyl-D-lactate residues,”Antimicrob. Agents Chemother., 1997, 41(1), 66-71.
Allen, N.E. et al., “Inhibition of Peptidoglycan Biosynthesis in Vancomycin-Susceptible and -Resistant Bacteria by a Semisynthetic Glycopeptide Antibiotic,”Antimicrob. Agents and Chemotherapy, 1996, 41(10), 2356-2362.
Arthur, M. et al., “Mechanisms of glycopeptide resistance in enterococci,”J. Infect., 1996, 32, 11-16.
Broker, T. R. et al, “Electron microscopic visualization of tRNA genes with ferritin-avidin: biotin labels,”Nucleic Acids Research, 1978, 5(2), 363-384.
Denome, S. A. et al., “Escherichia colimutants lacking all possible combinations of eight penicillin binding proteins: viability, characteristics, and implications for peptidoglycan synthesis,”J. Bacteriol., 1999, 181(13), 3981-3993.
Di Berardino, M. et al., “The monofunctional glycosyltransferase ofEscherichia coliis a member of a new class of peptidoglycan-synthesising enzymes,”FEBS Lett., 1996, 392(2), 184-188.
El-Abadla, N. et al., “Meonomycin A: The role of the methyl group in the moenuronamide unit and a general discussion of structure-activity relationships,”Tetrahedron, 1999, 55, 699-722.
Ge, M. et al., “Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala,”Science, 1999, 284, 507-511.
Hara, H. et al., “A novel glycan polymerase that synthesizes uncross-linked peptidoglycan inEscherichia coli,” FEBS Letts., 1984, 168(2), 155-160.
Ishino, F. et al., “Peptidoglycan synthetic enzyme activities of highly purified penicillin- binding protein 3 inEscherichia coli: a septum-forming reaction sequence,”Biochem. Biophys. Res. Commun., 1981, 101(3), 905-911.
Ishino, F. et al., “Dual enzyme activities of cell wall peptidoglycan synthesis, peptidoglycan transglycosylase and penicillin-sensitive transpeptidase, in purified preparations ofEscherichia colipenicillin-binding protein 1A,”Biochem. Biophys. Res. Commun., 1980. 97(1), 287-293.
Ishino, F. et al., “Peptidoglycan synthetic activities in membranes ofEscherichia colicaused by overproduction of penicillin-binding protein 2 and rodA protein,”J. Biol. Chem., 1986, 261(15), 7024-7031.
Langer, P. R. et al., “Enzymatic synthesis of biotin-labeled polynucleotides: Novel nucleic acid affinity probes,”Proc. Natl. Acad. Sci. USA, 1981, 78(11), 6633-6637.
Leclercq, R., “Les Glycopeptides: mécanismes d'action et de résistance,”La Presse Médicale, 1999, 28(13), 720-721 (English language translation provided).
Leclercq, R. et al., “Resistance to glycopeptides in enterococci,”Clin. Infect. Dis., 1997, 24, 545-554.
Malabarba, A. et al., “Structural modifications of glycopeptide antibiotics,”Med. Res. Rev., 1997, 17, 69-137.
Manning et al., “A Method for Gene Enrichment Based on the Avidin-Biotin Interaction. Application to theDrosophilaRibosomal RNA Genes,”Biochemistry, 1977, 16(7), 1364-1370.
Manning et al., “A New Method of in situ Hybridization,”Chromosoma, 1975, 53, 107-117.
Matsuhashi, M. 1994, “Utilization of lipid linked precursors and the formation of peptidoglycan in the process of cell growth and division: Membrane enzymes involved in the final steps of peptidoglycan synthesis and the mechanism of their regulation,” inBacterial Cell Wall: New Comprehensive Biochemistry, Ghuysen, J.-M. et al. (eds.), Elsevier, New York. 1994, vol. 27, 55-71.
Nagarajan, R., “Structure-activity relationships of vancomycin-type glycopeptide antibiotics,”J. Antibiot(Tokyo), 1993, 46, 1181-1195.
Paik, J. et al., “Mutational analysis of theStreptococcus pneumoniaebimodular class A penicillin-binding proteins,”J. Bacteriol., 1999, 181(12), 3852-3856.
Park, W. et al., “Major peptidoglycan transglycosylase activity inStreptococcus pneumoniaethat is not a penicillin binding protein,”FEMS Microb. Lett., 1985, 27, 45-48.
Park, W. et al., “Staphylococcus aureusandMicrococcus luteuspeptidoglycan transglycosylases that are not penicillin-binding proteins,”J. Bacteriol., 1984, 157(2), 538-544.
Schiffer, G. et al., “Cloning and biochemical characterization of the bifunctional penicillin-binding protein 1C fromEscherichia coli,”J. Biol. Chem., 1999, 274(45), 32031-32039.
Sharma, U. K. et al., “Expression and characterization of the ponA (ORF 1) gene ofHaemophilus influenzae: functional complementation in a heterologous system,”J. Bacteriol., 1995, 177(23), 6745-6750.
Sodja, A. et al., “Gene mapping and gene enrichment by the avidin-biotin interaction: use of cytochrome-c as a polyamine bridge,”Nucleic Acids Research, 1978, 5(2), 385-401.
Spratt, B. G. et al., “Microcorrespondence: Monofunctional biosynthetic peptidoglycan transglycosylases,”Mol. Microbiol., 1996, 19(3), 639-640.
Suzuki, H. et al., “In vitro peptidoglycan polymerization catalysed by penicillin binding protein 1b ofEscherichia coliK-12,”FEBS Lett., 1980. 110(2), 245-249.
Taku, A. et al., “Purification of the peptidoglycan transglycosylase ofBacillus megaterium,”J. Biol. Chem., 1982, 257(9), 5018-5022.
van Heijenoort, Y. et al., “Polymerization by transglycosylation in the biosynthesis of the peptidoglycan ofEscherichia coliK 12 and its inhibition by antibiotics,”FEBS Lett., 1978, 89(1), 141-144.
van Heijenoort, Y. et al., “Biosynthesis of the peptidoglycan ofEscherichia coliK-12: properties of the in vitro polymerization by transglycosylation,”FEBS Lett., 1980, 110(2), 241-244.
van Heijenoort, Y. et al., “Membrane intermediates in the peptidoglycan metabolism ofEscherichia coli: possible roles of PBP 1b and PBP 3,”J. Bacteriol., 1992, 174(11), 3549-3557.
van Heijenoort, Y. et al., ERRATA: “Membrane intermediates in the peptidoglycan metabolism ofEscherichia coli: possible roles of PBP 1b and PBP 3,”J. Bacteriol., 1992, 174(11), 6004.
Wada, A. et al., “Penicillin-binding protein 1 ofStaphylococcus aureusis essential for growth,”J. Bacteriol., 1998, 180(10), 2759-2765.
Walsh, C.T. et al., “Bacterial resistance to vancomycin: five genes and one missing hydrogen bond tell the story,”Chem. Biol., 1996, 3, 21-28.
Walsh, C.T., “Vancomycin resistance: decoding the molecular logic,”Science, 1993, 261, 308-309.
Walsh, C.T., Corrections and Clarifications: “Vancomycin resistance: decoding the molecular logic,” Science, 1993, 261(5131), 164.
Williams, D.H., “The glycopeptide story—how to kill the deadly ‘superbugs’,”Nat. Prod. Rep., 1996, 13, 469-477.
Zijderveld, C. A. et al., “Hybrid proteins of the transglycosylase and the transpeptidase domains of PBP1B and PBP3 ofEscherichia coli,” J. Bacteriol., 1995, 177(21), 6290-6293.
U.S. Appl. No. 09/241,862.
Tanaka, H. et al., “Studies on bacterial cell wall inhibitors. II. Inhibition of peptidoglycan synthesis in vivo and in vitro by amphomycin,”Biochim Biophys Acta,Netherlands, 1977, 497 (3), 633-640.
Zemel, R.I., et al., “Pyruvate-uridine diphospho-N-acetylglucosamine transferase. Purification to homogeneity and feedback inhibition,”J. Biol Chem, 1975, 250(8), 3185-92.
Branstrom Arthur A.
Goldman Robert C.
Advanced Medicine East, Inc.
Hines J.
Smith Lynette R. F.
Woodcock & Washburn LLP
LandOfFree
Methods for assaying transglycosylase reactions, and for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for assaying transglycosylase reactions, and for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for assaying transglycosylase reactions, and for... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3376976