Optics: measuring and testing – By dispersed light spectroscopy – Utilizing a spectrometer
Reexamination Certificate
2005-05-04
2008-11-11
Evans, F. L (Department: 2877)
Optics: measuring and testing
By dispersed light spectroscopy
Utilizing a spectrometer
C356S073000, C356S419000, C382S133000
Reexamination Certificate
active
07450229
ABSTRACT:
Aspects of the present invention encompass the collection of multispectral images from a population of objects, and the analysis of the collected images to measure at least one characteristic of the population, using photometric and/or morphometric features identifiable in the collection of images. In an exemplary application, the objects are biological cells. In a particularly preferred, but not limiting implementation, the plurality of images for each individual object are collected simultaneously. In an empirical study, the characteristic being measured involves the synapse between conjugated cells. The conjugated cells may represent a subpopulation of the overall population of objects that were imaged. In a particularly preferred, yet not limiting embodiment, the present invention enables the quantization of the redistribution of cellular molecules due to the conjugation of different biological cells. Significantly, such quantization is not feasible with standard microscopy and flow cytometry.
REFERENCES:
patent: 3922069 (1975-11-01), Kishikawa et al.
patent: 4635293 (1987-01-01), Wantanabe
patent: 4677680 (1987-06-01), Harima et al.
patent: 4770992 (1988-09-01), Van den Engh et al.
patent: 4777525 (1988-10-01), Preston, Jr.
patent: 4786165 (1988-11-01), Yamamoto et al.
patent: 5096807 (1992-03-01), Leaback
patent: 5141609 (1992-08-01), Sweedler et al.
patent: 5153916 (1992-10-01), Inagaki et al.
patent: 5159397 (1992-10-01), Kosaka et al.
patent: 5159398 (1992-10-01), Maekawa et al.
patent: 5159642 (1992-10-01), Kosaka
patent: 5247339 (1993-09-01), Ogino
patent: 5247340 (1993-09-01), Ogino
patent: 5272354 (1993-12-01), Kosaka
patent: 5351311 (1994-09-01), Rogers
patent: 5422712 (1995-06-01), Ogino
patent: 5444527 (1995-08-01), Kosaka
patent: 5471294 (1995-11-01), Ogino
patent: 5548349 (1996-08-01), Mizuguchi et al.
patent: 5548395 (1996-08-01), Kosaka
patent: 5568315 (1996-10-01), Shuman
patent: 5596401 (1997-01-01), Kusuzawa
patent: 5633503 (1997-05-01), Kosaka
patent: 5644388 (1997-07-01), Maekawa et al.
patent: 5674743 (1997-10-01), Ulmer
patent: 5695934 (1997-12-01), Brenner
patent: 5754291 (1998-05-01), Kain
patent: 5760899 (1998-06-01), Eismann
patent: 5764792 (1998-06-01), Kennealy
patent: RE35868 (1998-08-01), Kosaka
patent: 5831723 (1998-11-01), Kubota et al.
patent: 5848123 (1998-12-01), Strommer
patent: 5855753 (1999-01-01), Trau et al.
patent: 5900942 (1999-05-01), Spiering
patent: 5929986 (1999-07-01), Slater et al.
patent: 5959953 (1999-09-01), Alon
patent: 6007994 (1999-12-01), Ward et al.
patent: 6014468 (2000-01-01), McCarthy et al.
patent: 6066459 (2000-05-01), Garini et al.
patent: 6116739 (2000-09-01), Ishihara et al.
patent: 6156465 (2000-12-01), Cao et al.
patent: 6210973 (2001-04-01), Pettit
patent: 6211955 (2001-04-01), Basiji et al.
patent: 6249341 (2001-06-01), Basiji et al.
patent: 6256096 (2001-07-01), Johnson
patent: 6259807 (2001-07-01), Ravkin
patent: 6330081 (2001-12-01), Scholten
patent: 6330361 (2001-12-01), Mitchell et al.
patent: 6381363 (2002-04-01), Murching et al.
patent: 6522781 (2003-02-01), Norikane et al.
patent: 6549664 (2003-04-01), Daiber et al.
patent: 6620591 (2003-09-01), Dunlay et al.
patent: 6763149 (2004-07-01), Riley et al.
patent: 7006710 (2006-02-01), Riley et al.
patent: 2001/0006416 (2001-07-01), Johnson
patent: 2001/0011018 (2001-08-01), Baum et al.
patent: 2002/0030812 (2002-03-01), Ortyn et al.
patent: 2002/0126275 (2002-09-01), Johnson
patent: WO 98/53093 (1998-11-01), None
patent: WO 98/53300 (1998-11-01), None
patent: WO 99/24458 (1999-05-01), None
patent: WO 00/14545 (2000-03-01), None
patent: WO 00/42412 (2000-07-01), None
patent: WO 01/46675 (2001-06-01), None
patent: WO 02/17622 (2002-02-01), None
Kubota, Fumio et al. 1995. “Flow Cytometer and Imaging Device Used in Combination.”Cytometry: 21:129-132.
Kubota, F. 2003. “Analysis of red cell and platelet morphology using an imaging-combined flow cytometer.”Clin. Lab. Haem.: 25:71-76.
Ong, Sim Heng. 1985. Development of a System for Imaging and Classifying Biological Cells in a Flow Cytometer. Doctor of Philosophy Thesis. University of Sydney, School of Electrical Engineering. (August).
Ong, S.H. et al. 1987. “Development of an Image Flow Cytometer.”Analytical and Quantitative Cytology and Histology. XIVth International Conference on Medical and Biological Engineering and the VIIth International Conference on Medical Physics, Finland. (August): 375-382.
Ong, S.H. and P.M. Nickolls. 1991. “Optical Design in a Flow System For Imaging Cells.”Sciences in Medicine: 14:2:74-80.
Ong, S.H. and P.M. Nickolls. 1994. “Analysis of MTF Degradation in the Imaging of Cells in a Flow System.”International Journal of Imaging Systems&Technology: 5:243-250.
Satoh, Kaneo et al. 2002. “Small Aggregates of Platelets Can Be Detected Sensitively by a Flow Cytometer Equipped With an Imaging Device: Mechanisms of Epinephrine-Induced Aggregation and Antiplatelet Effects of Beraprost.”Cytometry: 48:194-201.
Wang, Fu-sheng and Fumio Kubota. 2002. “A Novel Apoptosis Research Method With Imaging-Combined Flow Cytometer and HITC OR IR-125 Staining.”Cytometry: 50:267-274.
Wietzorrek, Joachim et al. 1999. “A New Multiparameter Flow Cytometer: Optical and Electrical Cell Analysis in Combination With Video Microscopy in Flow.”Cytometry: 35:291-301.
Hecht, Eugene. “Optics 4thed.” 2002. Addison-Wesley Longman, Inc., XP-002465391. ISBN: 0-8053-8566-5.
Gordy, Claire et al., “Visualization of antigen presentation by actin-mediated targeting of glycolipid-enriched membrane domains to the immune synapse of B cell APCs.” Journal of Immunology, vol. 172, No. 4, Feb. 15, 2004. pp. 2030-2038, XP002481372 ISSN: 0022-1767.
Basiji David A.
Lynch David H.
Ortyn William E.
Amnis Corporation
Anderson Ronald M.
Evans F. L
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