Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-02-08
2005-02-08
Meller, Michael (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S613000, C514S724000, C514S740000, C424S094500, C424S450000, C435S193000, C530S353000
Reexamination Certificate
active
06852686
ABSTRACT:
The present invention relates to the discovery of a method to provide stabilized transglutaminase 1 enzyme, involucrin, and other molecules necessary for the assembly of the cell envelope to skin cells. Novel biological tools, prophylactics, therapeutics, cosmetics, and methods of use of the foregoing for study, prevention, and treatment of skin disorders are also disclosed.
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Lai et al., “Sphingosylphosphocholine Reduces the Calcium Ion Requirement for Activating Tissue Transglutaminase” (Jun. 27, 1997) Journal of Biological Chemistry, 272(26), 16295-16300.□□□□.*
Candi, E., et al. (1998) Transglutaminase 1 Mutations in Lamellar Ichthyosis. J. Biol. Chem. 273(22): 13693-13702.
Marekov, L. N. and Steinert, P. M. (1998) Ceramides Are Bound to Structural Proteins of the Human Foreskin Epidermal Confirmed Cell Envelope. J. Biol. Chem. 273(28): 17763-17770.
Nemes, Z. and Steinert, P. M. (1999) Bricks and mortar of the epidermal barrier. Exp. Mol. Med. 31(1):5-19.
Nemes, Z., et al. (1999) A novel function for transglutaminase 1: Attachment of long-chain ω-hydroxyceramides to involucrin by ester bond formation. PNAS 96:8402-8407.
Nemes, Z., et al. (1999) Involucrin Cross-linking by transglutaminase 1 Binding to Membranes Directs Residue Specificity. J. Biol Chem. 274(16):11013-11021.
Steinert, P. (Presentation Apr. 19, 1999) Enzymatic Attachment of Ceramides to the Comified Cell Envelope. Gordon Research Conference on the Barrier Function of Mammalian Skin, Il Ciocco, Barga, Italy (Apr. 18-23, 1999).
Steinert, P. M., et al. (1998) Biochemical Evidence That Small Proline-rich Proteins and Trichohyalin Function in Epithelia by Modulation of the Biomechanical Properties of Their Cornified Cell Envelopes. J. Biol. Chem. 273(19):11758-11769.
Marekov Lyuben
Nemes Zoltan
Steinert Peter
Harle Jennifer Ione
Knobbe Martens Olson & Bear LLP
Meller Michael
The United States of America as represented by the Department of
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