Methods for altering fertility

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C424S133100, C424S135100, C424S143100, C424S145100, C424S158100, C424S172100

Reexamination Certificate

active

07001597

ABSTRACT:
The present invention relates to methods for enhancing fertility by reducing the activities and/or levels of circulating glycoprotein hormones having lutropin (LH) activity. The molecules of the invention are antibodies or other binding agents that reduce the biological activities of LH. The present invention also relates to novel methods for devising and/or selecting antibodies to specific portions of proteins including LH and human chorionic gonadotropin (hCG) to permit their biological activities to be reduced to desired degrees. The present invention also relates to the preparation of single subunit gonadotropins and gonadotropin antagonists for use in stimulating and inhibiting fertility and for controlling ovarian hyperstimulation. In a preferred embodiment, the present invention pertains to a method for stimulating fertility in mammals by reducing the activity of glycoprotein hormones having luteinizing hormone activity in circulation and thereby stimulating the production of follicle stimulating hormone which comprises administering to the mammal a therapeutically effective amount of a binding agent that binds luteinizing hormone.

REFERENCES:
patent: 5284778 (1994-02-01), Canfield et al.
patent: 5508261 (1996-04-01), Moyle et al.
patent: 9116922 (1991-11-01), None
Huston, Proc. Natl. Acad. Sci. 85:5879-5883, 1988.
Thau (1979) Fertil Steril 31(2):200.
Thau (1980) Fertil Steril 33(3):317.
Yamamcto (1984) Am J. Reprod Immunol 5(4):164 (abstract).
Moyle (1987) J Biol Chem 262 (35):16920, 1987.
Moyle et al, Journal of Biological Chemistry, 1990, vol. 265, pp. 8511-8518.
Tortola et al, Principles of Anatomy and Physiology (text), 1984, p. 791.
Clark, Protein Engineering of Antibody Molecules for Prophylactic and Theraputic Applications in Man, 1993, p. 1.
Fitzgerald et al, Journal of Animal Science, 1985, vol. 60, pp. 749-754. (abstract).
Dale et al, Human Reproduction, 1992, vol. 7, pp. 1085-1089. (abstract).

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