Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-19
1998-06-30
MacMillan, Keith
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514823, 514568, 514570, 514420, 514404, 514405, 514569, A61K 3144, A61K 3119, A61K 31415
Patent
active
057734534
ABSTRACT:
The present invention concerns methods for reducing cutaneous flushing in a patient to whom niacin is administered. According to the present method, two or more doses of a nonsteroidal anti-inflammatory drug are administered to a patient prior to administering niacin. Alternatively, the nonstcroidal anti-inflammatory drug can be administered concurrently with niacin administration. The nonstcroidal anti-inflammatory drug can be aspirin, ibuprofen, indomethacin, phenylbutazone, or naproxen. The nonsteroidal anti-inflammatory drug is administered in an amount effective to reduce cutaneous flushing caused by the niacin, and is administered in an amount up to 160 mg for aspirin and ibuprofen, 10 mg for indomethacin, and 100 mg for phenylbutazone and naproxen.
REFERENCES:
patent: 4965252 (1990-10-01), Kuhrts
patent: 5023245 (1991-06-01), Kuhrts
Andersson, Rolf G.G. et al., Acta pharmacol. et toxicol., 41:1-10 (1977).
Ding, Reinhard W. et al., Am. Coll. Clin. Pharm., Abstract.
Ding, Reinhard W. et al., 2nd Cardio. Pharm. Int'l. Symp., Abstract 6.
Ding, Reinhard W. et al., Abstract 7a.
Ding, Reinhard W. et al., Abstract 7 (pp. 09.31).
Ding, Reinhard W. et al., Clin. Pharmacol. Ther., 46(6):642-647 (1989).
Hamazaki, Tomohito et al., Elsevier Scientific Publishers Ireland, Ltd. (1985).
Helgason, C. M. et al., Stroke, 25:2331-2336 (1994).
Kaijser, L. et al., Medical Biology, 57:114-117 (1979).
King, James M. et al., Am. J. Med., 97:323-331 (1994).
Kreisberg, Robert A., Am. J. Med., 97:313-316 (1994).
Lasagna, Louis, JAMA, 271:709-710 (1994).
McKenney, James M. et al., JAMA 271:672-677 (1994).
Morrow, Jason D. et al., J. Invest. Dermatol., 98:812-815 (1992).
Morrow, Jason D. et al., Prostaglandins, 38:263-274 (1989).
Stern, Ralph H. et al., Clin. Pharmacol. Ther., 50(1):66-70 (1991).
Svedmyr, N. et al., Acta pharmacol. et toxicol., 41:397-400 (1977).
Whelan, Anne Marie et al., J. Fam. Prac., 34(2):165-168 (1992).
Wilkin, Jonathan K. et al., Clin. Pharmacol. Ther., 31(4):478-482 (1982).
Wilkin, Jonathan K. et al., Clin. Pharmacol. Ther., 38(3):273-277 (1985).
Kuhrts Eric H.
Morrow Jason D.
Roberts, II L. Jackson
Lipoprotein Technologies, Inc.
MacMillan Keith
Vanderbilt University
Waker William B.
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