Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2008-08-22
2011-12-20
Parkin, Jeffrey S. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S007240, C424S188100, C424S208100
Reexamination Certificate
active
08080369
ABSTRACT:
The present invention relates to methods to activate peripheral blood mononuclear cells. The present invention further provides methods for the identification of blocking agents of Tat protein activation of PBMCs and for identifying an active portion of a Tat polypeptide for incorporation as an immunogen in a vaccine. The present invention also provides an immunogen comprising an isolated variant of wild-type HIV Tat protein that exhibits reduced HIV priming of competent cells in comparison to the wild-type HIV Tat protein. The present invention further provides a diagnostic kit for identifying blocking agents for HIV Tat protein.
REFERENCES:
Hamy, F., et al., 1997, An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication, Proc. Natl. Acad. Sci. USA 94:3548-3553.
HIV Sequence Compendium 2006/2007, Leitner T, Foley B, Hahn B, Marx P, McCutchan F, Mellors J, Wolinsky S, and Korber B, Eds., Published by Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, NM, LA-UR 07-4826, pp. 588-589.
Atkuri, K. R., et al., 2007, Importance of culturing primary lymphocytes at physiological oxygen levels, Proc. Nat. Acad. Sci. 104(11):4547-4552.
Herzenberg Lenore A.
Sahaf Bita
Greenberg & Traurig, LLP
Lubit Beverly W.
Parkin Jeffrey S.
The Board of Trustees of the Leland Standford Junior University
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