Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Two or more cell types – per se – in co-culture
Reexamination Certificate
2005-02-01
2005-02-01
Wehbe, Anne M. (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Two or more cell types, per se, in co-culture
C435S325000, C435S372000, C435S373000, C435S377000, C435S006120, C435S007240, C424S093100, C424S093300, C424S093700, C424S192100
Reexamination Certificate
active
06849452
ABSTRACT:
The present invention relates to a process for activating natural killer cells comprising bringing NK cells into contact with dendritic cells in vitro, ex vivo or in vivo. The invention also relates to cell compositions comprising activated NK cells, NK cell-dendritic cell co-cultures or dendritic cells, and to their use to stimulate the cytolytic activity of NK cells or natural immunity in vivo. The invention also relates to a NK cell stimulation factor present in the dendritic cell membrane, and to triggering media and factor(s) for dendritic cells and to their use, either alone or in combination, to stimulate NK activity, in particular in vivo. The invention can be used to control NK cell activity in vitro, ex vivo or in vivo, in particular under pathological conditions.
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Fernandez Nadine
Zitvogel Laurence
Institut Gustave Roussy
Preston Gates Ellis & Rouvelas Meeds
Wehbe Anne M.
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