Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2005-06-28
2005-06-28
Wang, Shengjun (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S558000
Reexamination Certificate
active
06911474
ABSTRACT:
Methods, pharmaceutical compositions, and compounds for reducing body weight, modulating body lipid metabolism, and reducing food intake in mammals are provided. The compounds of the invention include fatty acid ethanolamide compounds, homologues and analogs of which the prototype is the endogenous fatty acid ethanolamide, oleoylethanolamide.
REFERENCES:
patent: 5618955 (1997-04-01), Mechoulam et al.
patent: 5631297 (1997-05-01), Pate et al.
patent: 5679667 (1997-10-01), Della Valle et al.
patent: 5847008 (1998-12-01), Doebber
patent: 5859051 (1999-01-01), Adams
patent: 5925672 (1999-07-01), Piomelli
patent: 5962012 (1999-10-01), Lin
patent: 5985282 (1999-11-01), Haveson
patent: 6068976 (2000-05-01), Briggs et al.
patent: 6090836 (2000-07-01), Adams
patent: 6090839 (2000-07-01), Adams
patent: 6096784 (2000-08-01), Lerner
patent: 6160000 (2000-12-01), Adams
patent: 6200998 (2001-03-01), Sahoo
patent: 6261595 (2001-07-01), Stanley
patent: 6271015 (2001-08-01), Gilula
patent: 6274608 (2001-08-01), Sauerberg
patent: 6344474 (2002-02-01), Maruani et al.
patent: 6348498 (2002-02-01), Calignano
patent: 6359010 (2002-03-01), Geracioti, Jr. et al.
patent: 2002/0035150 (2002-03-01), Piomelli
patent: 2003/0041340 (2003-02-01), Cravatt
patent: 2003/0149082 (2003-08-01), Makriyannis et al.
patent: 2003/0195226 (2003-10-01), Sit et al.
patent: WO 94/12466 (1994-06-01), None
patent: WO 97/27857 (1997-08-01), None
patent: WO 97/28149 (1997-08-01), None
patent: WO 97/36579 (1997-10-01), None
patent: WO 98/20119 (1998-05-01), None
patent: WO 98/24396 (1998-06-01), None
patent: WO 99/60987 (1999-12-01), None
patent: WO 02/080903 (2002-10-01), None
Calignano et al.; “Control of pain initiation by endogenous cannabinoids”;Nature; Jul. 16, 1998; vol. 394; pp. 277-281; Macmillan Publishers Ltd.
Piomelli et al.; “Structural determinants for recognition and translocation by the anandamide transporter”;Proc. Natl. Acad. Sci. USA; May 1999; vol. 96; pp. 5802-5807.
U.S. Appl. No. 10/642,462, filed Aug. 2003, Piomelli et al.
U.S. Appl. No. 60/485,062, filed Jul. 2003, Fu et al.
U.S. Appl. No. 10/681,858, filed Oct. 2003, Piomelli et al.
Auboeuf, D. et al., “Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferators-activated receptors and liver X receptor-α in humans”Diabetes46:1319-1327 (1997).
Ahern, G. P. “Activation of TRPV1 by the satiety factor oleoylethanolamide”J. Biological Chemistry278(33):30429-30434 (Aug. 15, 2003).
Calignano, A. et al., “Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide”Eur. J. Pharmacol, 419(2-3):191-8 (2001).
Desvergne, B. et al., “Peroxisome proliferators-activated receptors: Nuclear control of metabolism”Endocrine Rev. 20(5):649-688 (1999).
Di Tomaso, E. et al., “Endogenous lipids that activate cannabinoid receptors. Formation and inactivation”Adv. Exp. Med. Biol. 407:335-40 (1997).
Fu, J. et al., “Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha”Nature425(6953):90-3 (2003).
Gaetani, S. et al., “Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide”Neuropsychopharm. 28(7):1311-6 (2003).
Gomez, R. et al., “A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding” J.Neurosci, 22(21):9612-7 (2002).
Kersten, S. et al., “Roles of PPARs in health and disease”Nature405:421-424 (2000).
Kliewer, S. et al., “Peroxisome proliferators-activated receptors: from genes to physiology”Recent Prog Horm Res56:239-63 (2001).
Loviscach, M. et al., “Distribution of peroxisome proliferators-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action”Diabetologia43(3):304-11 (2000).
Mechoulam, R. et al., “A hunger for cannabinoids”Nature410:763-765 (2001).
Memon, R. et al., “Up-regulation of peroxisome proliferators-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice”Endocrinology141(11):4021-31 (2000).
Moya-Camarena, S. et al., “Conjugated linoleic acid activates peroxisome proliferators-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats”Biochim Biophys Acta1436(3):331-42 (1999).
Piomelli, D. et al., “The endocannabinoid system as a target for therapeutic drugs”Trends Pharmacol Sci. 21(6):218-24 (2000).
Raloff, J. “Science News Online- Food for Thought: ‘Prescription-strength chocolate’” at <http://www.sciencenews.org/sn_arch/10_12_96/food.htm> (Visited Sep. 10, 2003).
Regents of the University of California, “Natural, marijuana-like chemical may provide treatment for obesity- Study in Nature shows reduced feeding, weight gain” at <http://www.ucihealth.com/News/Releases/obesity_marijuana.htm> Nov. 7, 2001.
Schoonjans, K. et al., “The peroxisome proliferators activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation”Biochim Biophys Acta1302 (2):93-109 (1996).
Stella, N. et al., “Receptor-dependent formation of endogenous cannabinoids in cortical neurons”Eur. J. Pharmacol. 425(3):189-96 (2001).
Tomaso, E. et al., “Brain cannabinoids in chocolate”Nature382(Aug. 22):677 (1996).
H.O. Schmid, et al., “The N-acylation-phosphodiesterase pathway and cell signalling,”Chem. Phys. Lipids, (1996), vol. 80, pp. 133-142.
K.D. Chapman, “Emerging physiological roles for N-acylphosphatidylethanolamine metabolism in plants: signal transduction and membrane protection,”Chem. Phys. Lipids, (2000), vol. 108:22, pp. 221-229.
V. D. Marzo, et al., “Formation and inactivation of endogenous cannabinoid anandamide in central neurons,”Nature, (1994), vol. 372, pp. 686-691.
A. Giuffrida, et al., “Dopamine activation of endogenous cannabinoid signaling in dorsal striatum,”Nat. Neurosci., (1999), vol. 2, No. 4, pp. 358-363.
E. Berdyshev, et al., “Stress-induced generation of IN-acylethanolamines in mouse epidermal JB6 P+ cells,”Biochem, J., (2000), vol. 346, pp. 369-374.
H. Cades, et al., “Biosynthesis of an Endogenous Cannabinoid Precursor in Neurons and its Control by Calcium and cAMP,”J. NeuroSci., (1996), vol. 16, pp. 3934-3942.
W. A. Devane, et al., “Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor,”Science, (1992), vol. 258, pp. 1946-1949.
G. Griffin, et al., “Cloning and Pharmacological Characterization of the Rat CB2Cannabinoid Receptor,”J. Pharmacol. Exp. Ther., (2000), vol. 292, No. 3, pp. 886-894.
A. Calignano, et al., “Control of pain initiation by endogenous cannabinoids,”Nature, (1998), vol. 394, pp. 277-281.
B. M. Forman, et al., “Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferators-activated receptors α and δ,”PNAS, (1997), vol. 94, pp. 4312-4317.
F. Desamaud, et al., “Anandamide Amidohydrolase Activity in Rat Brain Microsomes,”J. Biol. Chem., (1995), vol. 270, No. 11, pp. 6030-6035.
A. Giuffrida and D. Piomelli, “Purification and High-Resolution Analysis of Anandamide and Other Fatty Acylethanolamides,” in S. G. Laychock, ed. and R. P. Rubin, ed.Lipid Second Messengers, CRC Press LLC, Boca Raton, Florida, (1999), pp. 113-133.
A. Giuffrida, et al., “Quantification of Bioactive Acylethanolamides in Rat Plasma by Electrospray Mass Spectrometry,”Anal. Biochem., (2000), vol. 280, pp. 87-93.
A. Calignano, et al., “Bidirectional control of airway responsiveness by endogenous ca
de Fonseca Fernando Rodriguez
Piomelli Daniele
Kim Jennifer
The Regents of the University of California
Townsend and Townsend / and Crew LLP
Wang Shengjun
LandOfFree
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