Methods, apparatus and computer program products for...

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

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C702S022000, C703S011000, C703S012000

Reexamination Certificate

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07742877

ABSTRACT:
Methods, apparatus and computer program products are provided for identifying a component of culture medium based on the parameters (e.g., physical, chemical, biological and/or topological characteristics) of compounds from within a compound library. In preferred embodiments, the compound library is a peptide library. Also provided are methods of selecting a compound library from a larger compound space based on whole molecule (i.e., global) parameters of the compounds. Preferably, this method is practiced in conjunction with a method of identifying a component of a culture medium. Further provided are methods of predicting a biological activity of a peptide based on at least one whole molecule parameter of the peptide. This method finds use in methods of drug discovery, identifying components of culture medium, and identifying and/or designing peptides with particular pharmacological or therapeutic activities.

REFERENCES:
patent: 5510240 (1996-04-01), Lam et al.
patent: 6240374 (2001-05-01), Cramer et al.
patent: 2003/0162289 (2003-08-01), Campbell et al.
Tenson, Tanel et al., Journal of Biological Chemistry, 272:17425-17430, Jul. 1997.
Ostrem, James A. et al., Biochemsitry, 37:1053-1059, Jan. 1998.
“Webster's New World Dictionary, Third College Edition” (1988) Simon & Schuster, Inc.
Hellberg et al., “Minimum Analog Peptide Sets for Quantitative Structure-Activity Relationships”Int J Peptide Protein Res(1991) 37:414-24.
Nomura, Kohji. Dec. 1986. “Specificity of prolyl endopeptidase.” FEBS 4293, vol. 209, No. 2. pp. 235-237.
Odake, Shinjiro, et al. 1991. “Vertebrate Collagenase Inhibitor II. Tetrapeptidyl Hydroxamic Acids.” Chem. Pharm. Bull., vol. 39, No. 6. pp. 1489-1494.
Patterson, C. A. And W. M. Ingledew. 1999. “Utilization of Peptides by a Lager Brewing Yeast.” J. Am. Soc. Brew. Chem., vol. 57, No. 1. pp. 1-8.
Davis et al. 1973. “Corynebacterium Diphtheriae.” pp. 682-692. (Omitted Book Title): Microbiology, Oct. 11, 2005.
Bause, Ernst. 1983. “Structural Requirements of N-glycosylation of Proteins.” Biochemical Journal, vol. 209. pp. 331-336.
Vyas, Jatin M. et al. 1992. “Biochemical Specificty of H2M3.” Journal of Immunology, vol. 149. pp. 3605-3611.
Invitrogen catalog, accessed from www.invitrogen.com on Jul. 27, 2005.
O'Shea et al. “Morphological Characterization of the Dimorphic Yeast Kluyveromyces marxianus var. marxianus NRRLy24I5 by Semi-Automated Image Analysis” Biotechnology and Bioengineering, (1996) vol. 51, pp. 679-690.
Automated Cell Technologies; In Vivo: The Business and Medicine Report, Windhover Information Inc., Dec. 1997, p. 38.
Cho et al.;Rational Combinatorial Library Design. 2. Rational Design of Targeted Combinatorial Peptide Libraries Using Chemical Similarity Probe and the Inverse QSAR Approaches, J. Chem. Inf. Comput. Sci., 38:259-268 (1998).
Cocchi et al.;Amino Acids Characterization by GRID and Multivariate Data Analysis, Quant. Struct.-Act. Relat. 12:1-8 (1993).
Gibbs et al.;Some Factors Governing the Production of Diphtheria Toxin in Artificial Culture Media, The Journal of Immunology, XIII:323-344 (1927).
Hellberg et al.;Peptide Quantitative Structure-Activity Relationships, a Multivariate Approach, J. Med. Chem. 30:1126-1135 (1987).
Kihara et al.;Peptides and Bacterial Growth III. Utilization of Tyrosine and Tyrosine Peptides by Streptococcus faecalis, The Journal of Biological Chemistry, 197:2 801-807 (1952).
Norinder;Theoretical Amino Acid Descriptors. Application to Bradykinin Potentiating Peptides, Peptides, 12:1223-1227 (1991).
Sneath;Relations Between Chemical Structure and Biological Activity in Peptides, J. Theoret. Biol., 12:157-195 (1966).
Zhao;Isolation and Characterization of a Bacterial Growth-Stimulating Peptide from a Peptic Bovine Hemoglobin Hydrolysate, Appl. Microbiol Biotechnol, 45:778-784 (1996).
Zheng et al.;Rational Combinatorial Library Design. I. Focus-2D: A New Approach to the Design of Targeted Combinatorial Chemical Libraries, J. Chem. Inf. Comput. Sci., 38:251-258 (1998).

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