Methods and uses of leukotriene B 4 hydroxylases to treat...

Details Methods and uses of leukotriene B 4 hydroxylases to treat... Methods and uses of leukotriene B 4 hydroxylases to treat...

2008-03-11

2008-03-11

Crane, L. E. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S045000, C514S047000

Reexamination Certificate

active

11414896

ABSTRACT:
Methods and uses are described for treating or preventing diseases of humans or non-human animals by reducing the amount of active leukotriene B4(LTB4) in those in need of such treatment using LTB4hydroxylases. In certain embodiments, LTB4hydroxylase is administered in combination with nicotinamide adenine dinucleotide phosphate and/or an NADPH-cytochrome P-450 reductase. The invention is particularly useful for treating or preventing respiratory diseases that are caused or exacerbated by inflammation.

REFERENCES:
Powell, W.S., J. Biological Chemistry, 1984, vol. 259, No. 5, pp. 3082-3089.
Kawashima, H., Archives of Biochemistry and Biophysics, 1997, vol. 347, No. 1, pp. 148-154.
P. M. O'Byrne, Leukotriene B4 Induces Airway Hyperresponsiveness in Dogs, Journal of Applied Physiology, vol. 59, Issue 6 1941-1946, 1985.
Zsuzsanna Csoma, Increase Leukotrienes in Exhaled Condensate in Childhood Asthma, Am J Respir Crit Care Med, vol. 166. pp. 1345-1349, 2002.

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