Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2004-10-08
2011-10-25
Shafer, Shulamith H (Department: 1647)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds hormone or other secreted growth regulatory factor,...
C424S130100
Reexamination Certificate
active
08043619
ABSTRACT:
The present invention describes the use of leptin for the immune modulation of the Th1/Th2 response. One aspect of the invention provides for a shift in the Th1/Th2 cell balance towards pro-inflammatory cytokine producing cells. This shift results from an increase in the levels, expression and/or the activity of leptin. Another aspect of the invention provides for a shift in the Th1/Th2 cell balance towards anti-inflammatory cytokine producing cells. This shift results from a decrease in the levels, expression and/or the activity of leptin. The shifting of the Th1/Th2 balance provides a method for the treatment of a variety of diseases and disorders.
REFERENCES:
patent: 6124439 (2000-09-01), Friedman et al.
patent: 2004/0043026 (2004-03-01), Tuan et al.
patent: 2004/0229783 (2004-11-01), Pothoulakis et al.
patent: 2006/0040861 (2006-02-01), Iwamoto
patent: 2006/0046959 (2006-03-01), Tavernier et al.
patent: WO 99/59614 (1999-11-01), None
2005. Peelman et al. Current Pharm Design 11:539-548.
Matarese et al. 2002. Current Drug Targets-Inflammation and Allergy. 1:13-22.
Iversen et al. 2002. Blood 100:4123-4128.
Majno 1998. Am J of Pathology 153:1035-1039.
Murad et al. 2003. FASEB Journal. 17:1895-1909, epub Aug. 15, 2003.
Diegelmann et al. 2004. Front Biosci. 9:283-9 (Abstract only).
Sachot et al. 2004. J Physiol 561 (Pt1):263-72.
Konstantinides et al. 2004. Arterioscler Thromb Vasc Biol 24:2196-2201, epub Sep. 30, 2004.
Pucilowska et al 2000. Am J. Physiol Gastrointest Liver Physiol. 279:G653-G659.
Elinav Eran
Ilan Yaron
Boqdanos, Esq. Natalie
Gendloff, Esq. Elie H.
Shafer Shulamith H
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