Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-02-13
2010-06-29
Nickol, Gary B (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S389200, C530S413000, C436S001000, C424S184100, C514S012200
Reexamination Certificate
active
07745147
ABSTRACT:
The present invention provides improved methods and uses of an immunoglobulin in the purification of an interferon composition. The methods of the invention provide for the use of a monoclonal antibody in the purification of an interferon composition comprising a plurality of interferon alpha subtypes. The use of the monoclonal antibody provides for the production of an interferon composition with a consistent proportion of interferon subtypes, providing a resulting improvement in simplicity of production of the resulting interferon composition.
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patent: WO 2006/085092 (2006-08-01), None
Andersson, et al. “Application of Four Anti-Human Interferon-α Moncolonal Antibodies for Immunoassay and Comparative Analysis of Natural Interferon-α Mixtures”,Journal of Interferon Research, 11:53-60 (1991).
Tolo, et al. “Development of a Highly Purified Multicomponent Leukocyte IFN-α Product”,Journal of Interferon and Cytokine Research21:913-920 (2001).
Kandefer-Szerszen, et al. “Three Separate Epitopes on Human IFN—α Variants Defined by Monoclonal Antibodies and Their Role in the Binding to Receptors”,Archivum Immunologiac at Therapiae Experimentalis, 1992, 40, 241-246.
Lundgren, et al. “Interferon-α: a gene family in therapeutic use”,Journal of Pharmaceutical&Biomedical Analysis, vol. 7, No. 2, pp. 233-238, 1989.
Lundberg Sven
Lundgren Erik
Robertson Colin
Smith Julie
Drinker Biddle & Reath LLP
Hamud Fozia M
Nickol Gary B
ViraNative AB
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