Methods and use of motoneuronotrophic factors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S300000, C530S350000, C530S399000

Reexamination Certificate

active

06841531

ABSTRACT:
The invention is directed to a method of administering motoneuronotrophic factors for promoting the survival, growth, proliferation, or maintenance of mammalian neurons. The method is useful for promoting the survival, growth, proliferation, regeneration, or maintenance of mammalian neurons, promoting axonal regeneration, for inhibiting the effects of hereditary motoneuron disease, for minimizing or inhibiting the effects of scar tissue formation, and for accelerating wound healing while concomitantly minimizing or inhibiting the effects of scar tissue and keloid formation.

REFERENCES:
Jackowski (1995) “Neural Injury repair: hope for the future as barriers to effective CNS regeneration become clear,” British Journal of Neurosurgery 9: 303-317.*
Lee & Wolfe (Jul./Aug. 2002) “Peripheral Nerve Injury and Repair.” J. Am. Acad. Orthop. Surg. 8(4): 243-252.*
Wells (Sep. 18, 1990) “Additivity of Mutational Effects in Proteins.” Biochemistry 29(37): 8509-8517.*
Ngo et al. (Mar. 2, 1995) “The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14: Computational Complexity Protein Structure Prediction, and the Levinthal Paradox” pp. 492-495.*
Bork (2000) “Powers and Pitfalls in Sequence Analysis: The 70% Hurdle.” Genome Research 10:398-400.*
Skolnick and Fetrow (2000) “From gene to protein structure and function: novel applications of computational approaches in th genomic era.” Trends in Biotech. 18(1): 34-39.*
Doerks et al., (Jun. 1998) “Protein annotation: detective work for function prediction.” Trends in Genetics 14(6): 248-250.*
Smith and Zhang (Nov. 1997) “The challenges of genome sequence annotation or ‘The devil is in the details’.” Nature Biotechnology 15:1222-1223.*
Brenner (Apr. 1999) “Errors in genome annotation.” Trends in Genetics 15(4): 132-133.*
Bork and Bairoch (Oct. 1996) “Go hunting in sequence databases but watch out for the traps.” Trends in Genetics 12(10): 425-427.*
Nolte (1999) The Human Brain: An Introduction to Its Functional Anatomy 4th Ed. Chapter 18: Overview of Motor Systems. pp. 434-449.*
Kandel et al. (2000) Principles of Neural Science 4th Ed. Chapter 33: The Organization of Movement pp. 663-673.*
Yu et al. (Jul. 1, 1994) “Muscle-Derived Motoneuronotropic Factors Promote Survival of Axotomized Motoneurons of the Facial Nerve.” Society for Neuroscience Abstracts 18(Part 2): 1296 (Abstract #546.15).*
Liuzzi and Tedeschi (Jan. 1991) “Peripheral Nerve Regeneration.” Surgical Management of Peripheral Nerve Injury and Entrapment 2(1): 31-42.*
Evans (Aug. 1, 2001) “Peripheral Nerve Injury: A Review and Approach to Tissue Engineered Constructs.” The Anatomical Record 263(4): 396-404.*
Jacob et al. (Jul. 2001) “Mechanisms and molecules in motor neuron specification and axon pathfinding.” BioEssays 23(7): 58 595.*
Welch (Nov. 1996) “Peripheral Nerve Injury.” Seminars in Veterinary Medicine and Surgery (Small Animal) 11(4): 273-28.*
Kassar-Duchossoy et al. (Jul. 20, 2001) “Reinervation of a denervated skeletal muscle by spinal axons regenerating through a collagen channel directly implanted into the rat spinal cord.” Brain Research 908(1): 25-34.*
Chau, R.M.W. et al.: “Biological effect of motoneuronotrophic factor on wobbler mice with motoneuron disease” 26thAnnual Meeting of the Society for Neuroscience. vol. 22, No. 1-3. Nov. 16-21, 1996. Washington, D.C., USA. p. 233 XP002067887. Abstract only.
Chau, R.M.W. and Jen, L. S.: Muscle neuronotrophic factors specific for anterior horn motoneurons of rat spinal cord. In: Recent Advances In Cellular And Molecular Biology. Wegmann, R.J. and Wegmann, M.A. (Eds). Peeters Press, Leuven, Belgium, 1992. vol. 5, pp. 89-94.
Chau, R.M.W. et al.: “Cloning of genes for muscle-derived motoneuronotrophic factor 1 (MNTF1) and its receptor by monoclonal antibody probes,” Society for Neuroscience Abstracts, vol. 19, 1993. p. 252 XP002067890, Abstract only.
Minghua, Z., Chau, R.M.W., Ren, F.. Huang, W.Q., Ren, L. Production and assessment of monoclonal antibodies specific for the 35kD motoneuronotrophic factor from rat skeletal muscle. Journal of Monoclonal Antibody, 1992, vol. 8(3), Abstract only.
Ming-Hua, Z. (Chau RMW), Yu, W., Ren, F. Changes in moto-neuronotrophic factor and its receptor in tongue muscle post-denervation of the hypoglossal nerve. Department of Anatomy, University of Hong Kong; Department of Cell Biology and Anatomical Sciences, City University of New York Medical School, New York, USA, 1993, 391-395, Abstract only.
Wang, A., Chau, R.M.W., Zhou, Z. et al. Effects of myogenic 22.35kD neurotrophic factors on axonal regeneration in free peripheral nerve auto-grafts implanted into rat spinal cord. Chinese Journal of Spine and Spinal Cord, 1995, 5(6):248, Abstract only.
Yu, W.H.A., Chau, R.M.W. and Ren, F. Muscle-derived motoneuronotrophic factors promote survival of axotomized motoneurons of the facial nerve. Abstracts. Society for Neuroscience, 22ndAnnual Meeting 1992, 546.15, Abstract only.
Zhou, Ming-Hua, Ren, Feng and Zhao, Li-Ping, Identification of a 12.5-kD Protein From Caudate-Putamen Nucleus as a Dopaminergic Neuronotrophic Factor. Department of Anatomy, University of Hong Kong, Hong Kong, 1993.
Chau, R.M.W., Ren, F. and Huang, W.Q. Programmed Cell Death of Neonatal Rat Retinal Ganglion Cells due to Turn-Off Expression of a Novel 30-kD Trophic Factor and/or the Lack of this Factor Supplied from the Superior Colliculus. Department of Anatomy, University of Hong Kong, Hong Kong. Aging and Cellular Mechanisms, vol. 663 of theAnnals of the New York Academy of Sciences, Nov. 21, 1992.
Chau, R.M.W. et al.: “Muscle neurotrophic factors specific for anterior horn motoneurons of rat spinal cord.” Recent Advanced in Cellular and Molecular Biology, vol. 5, 1991, pp. 89-94, XP002063339.

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