Perfume compositions – Perfume compositions – With preservative – stabilizer – or fixative
Patent
1992-09-21
1996-12-31
Fleisher, Mindy
Perfume compositions
Perfume compositions
With preservative, stabilizer, or fixative
530399, 530350, 4352402, A61K 3818, C12N 506, C07K 14485, C07K 14475
Patent
active
055894518
ABSTRACT:
The invention relates to the use of hepatocyte and keratinocyte growth factors for controlling the proliferation and motility of corneal cells in vivo and in vitro. It also relates to the use of these factors for maintaining the viability of the corneal cells during or after ocular surgery and during corneal preservation in storage medium prior to transplant. Polymerase chain reaction amplification has demonstrated that corneal epithelial and endothelial cells in vitro and ex vivo corneal epithelium produce messenger RNA coding for hepatocyte growth factor, hepatocyte growth factor receptor, keratinocyte growth factor, and keratinocyte growth factor receptor. Additionally, it was demonstrated that hepatocyte growth factor and keratinocyte growth factor stimulate the proliferation of corneal epithelial cells and corneal endothelial cells in vitro in a dose response manner.
REFERENCES:
patent: 5032575 (1991-07-01), Neufeld
Stoker et al. Nature 327 pp. 239-242 May 1987.
Jacob et al. Eye vol. 3 sts pp. 618-625 1989.
Marchesi et al. J. Cell. Phys 144 pp. 326-332 Aug. 1990.
Wilson et al. Invest Opthalmol. U.S. Sci (US) 34(8) pp. 2544-2561 Jul. 1993.
Wilson et al., "EGF, EGF Receptor, Basic FGF, TGF Beta-1, and IL-1 Alpha mRNA in Human Corneal Epithelial Cells and Stromal Fibroblasts," Investigative Ophthalmology & Visual Science, 33(5):1756-1765, 1992.
Wilson and Lloyd, "Epidermal Growth Factor and Its Receptor, Basic Fibroblast Growth Factor, Transforming Growth Factor Beta-1, and Interleukin-1 Alpha Messenger RNA Production in Human Corneal Endothelial Cells," Investigative Ophthalmology & Visual Science, 32(10):2747-2756, 1991.
Dialog Search Report dated Jul. 20, 1992.
Board of Regents , The University of Texas System
Fleisher Mindy
Schmickel David
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