Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2006-10-10
2006-10-10
Woitach, Joseph (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S003000, C800S008000, C800S009000, C435S325000
Reexamination Certificate
active
07119249
ABSTRACT:
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The present invention additionally comprises cells and cell lines containing transgenes encoding for members of the NOX and Duox family of proteins. The present invention further comprises methods and compositions for evaluating regulators of abnormal cell growth and in the development of compounds that effect ROI expression.
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Suh et al., “Cell transformation by the superoxide-generating oxidase Mox1,” Nature 401:79-82, 1999.
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Cheng et al., “Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, Nox5,” Gene 269: 131-140, 2001.
Edens et al., “Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox,” Journal of Cell Biology 154(4): 879-891, 2001.
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Cheng Guangjie
Lambeth J. David
McCoy James
Emory University
Klarquist & Sparkman, LLP
Ton Thai-an N.
Woitach Joseph
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