Methods and test kit for diagnosing/monitoring cancer in humans

Details Methods and test kit for diagnosing/monitoring cancer in humans Methods and test kit for diagnosing/monitoring cancer in humans

1983-09-16

1987-05-12

Warren, Charles F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 7, 435 68, 4351722, 435810, 436536, 436537, 436542, 436548, 436 64, 436 94, 436804, 436808, 436809, 436813, 436815, 436822, G01N 33577, G01N 33574

Patent

active

046650180

ABSTRACT:
Human cancer is diagnosed/monitored by measuring the levels of certain modified nucleosides, such as N-[(.beta.-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, in the urine of a subject by a quantitative immunoassay that preferably employs a monoclonal anti-modified nucleoside antibody and comparing that level to the level of the modified nucleoside that occurs in the urine of normal subjects to determine whether the former is substantially elevated over the latter or by comparing that level to the level of the modified nucleoside present in urine specimens taken from the subject at different times.

REFERENCES:
Vold, B. S. et al., Cancer Research, vol. 42 (12, part 1), pp. 5265-5269 (1982), Chem. Abst. 98(5):30763s.
Cimino, F. et al., Biochem. SAM Related Compd. Proc. Conf. 1981, pp. 409-412, MacMillan, London UK (1982), in Chem. Abst. 99(1):3656y.
Vold, B. S. Nucleic Acids Research, vol. 7(1), pp. 193-204 (1979), Chem. Abst. 91(25):206763p.
Clark, I. et al., Recent Results Cancer Res., vol. 84, pp. 388-400 (1983) in Chem. Abst. 99(1):3654w.
Thomale, J. et al., Recent Results Cancer Res., vol. 84, pp. 378-387 (1983), in Chem. Abst. 99(1):3653v.
Hirschborn, R. et al., Pediatr. Res., vol. 16(5), pp. 362-369 (1982), in Chem. Abst. 97(1):4522t.
Schoech, G. et al., Clin. Chim. Acta, vol. 108(2), pp. 247-257 (1980), in Chem. Abst. 94(11):79512r.
Gehrke, C. W. et al., J. Chromatography., vol. 188(1), pp. 129-147 (1980), in Chem. Abst. 92(15):124295u.
Uziel, M. et al., NTIS Report & Conf.-760336-1, 34 pages (1976), in Chem. Abst. 85(25):188551n.
Uziel, M. et al., Clin. Chem., vol. 22(9), pp. 1451-1455 (1976), in Chem. Abst. 85(21):1559222f.
Hong, C. I., Biochem. Pharmacol., vol. 22(15), pp. 1927-1936 (1973), "Metabolism of t6A in Rat and Man".
Chheda, G. B., Life Sci., vol. 8 (18 Pt. Z), pp. 979-987 (1969), "Isolation and Characterization of a Novel Nucleoside, t6A, from Human Urine."
Engvall, E., Methods in Enzymology, vol. 70, pp. 419-438 (1980).
Nishimura, S., Transfer RNA: Structure, Properties, and Recognition, Shimmel, P. R., et al., eds., Cold Spring Harbor Laboratory (1979), pp. 59-79.
Borek, E., et al., Cancer Res. (1977), 37:3362-3366.
Nomura, Y., FEBS Lett. (1974), 45:223-227.
Gehrke, C. W., et al., Cancer Res. (1979) 39:1150-1153.
Speer, J., et al., Cancer (1979) 44:2120-2123.
Borek, E., Cancer Markers (1980) ed. Sell, S. Humana Press, pp. 445-462.
Levine, et al., J. Natl. Cancer Inst. (1975) 54:341-343.
Milstone, et al., Nucl. Acids Res. (1978) 5:3439-3455.
Vold, B., Nucl. Acids Res. (1979) 7:193-204, 7:971-980.

Affiliated with

Also associated with

Rating

Methods and test kit for diagnosing/monitoring cancer in humans does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and test kit for diagnosing/monitoring cancer in humans, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and test kit for diagnosing/monitoring cancer in humans will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1802374