Methods and targets of antibiotic resistance

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

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C435S006120, C435S440000, C435S441000

Reexamination Certificate

active

06875582

ABSTRACT:
The present invention provides for a method of evolving and selecting cells resistant to a selective agent by inducing directed evolution in continuous culture while applying both a mutagenic and selective agent to the cells to determine the cells having resistance. This also provides a method of generating mutant drug targets useful for screening for effective compounds. The Figure is ageneralized schematic diagram of a chemostat of the present invention

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