Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2008-01-15
2008-01-15
Jaworski, Francis J. (Department: 3768)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S443000
Reexamination Certificate
active
10731302
ABSTRACT:
Methods and systems for measuring mechanical property of a vascular wall and a method and system for determining health of a vascular structure are provided wherein local deformation of a vessel wall resulting from physiologic pressures with altered transmural forces is measured. A non-invasive free-hand ultrasound scanning-procedure was performed to apply external force, comparable to the force generated in measuring a subject's blood pressure, to achieve higher strains by equalizing the internal arterial baseline pressure. When the applied pressure matched the internal baseline diastolic pressure, strain and strain rate increased by a factor of 10 over a cardiac cycle. Radial arterial strain was assessed in the vessel wall over the entire deformation procedure using a phase-sensitive, two-dimensional speckle-tracking algorithm. An elastic modulus reconstruction procedure was developed to estimate the non-linear elastic properties of the vascular wall.
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Chen Xunchang
Kim Kang
O'Donnell Matthew
Rubin Jonathan M.
Weitzel William F.
Brooks & Kushman P.C.
Jaworski Francis J.
The Regents of the University of Michigan
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