Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2005-03-04
2010-06-22
Le, Long V (Department: 3768)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C436S173000, C324S307000
Reexamination Certificate
active
07742800
ABSTRACT:
A method for increasing sensitivity and/or specificity of a magnetic resonance spectroscopy imaging technique for detecting a neurodegenerative disease is provided. The method includes acquiring magnetic resonance spectroscopy data from the brain of a subject, while suppressing certain metabolites in the spectrum via a data acquisition protocol, to improve quantification accuracy for the remaining metabolites, and quantifying a metabolite concentration or a metabolite concentration ratio from the spectral data as an indicator of the neurodegenerative disease.
REFERENCES:
patent: 5617861 (1997-04-01), Ross et al.
patent: 5657757 (1997-08-01), Hurd et al.
patent: 5924987 (1999-07-01), Meaney et al.
patent: 6069478 (2000-05-01), Hurd
patent: 6104191 (2000-08-01), Hurd
patent: 6147492 (2000-11-01), Zhang et al.
patent: 2002/0142367 (2002-10-01), Ke et al.
patent: 2002/0173713 (2002-11-01), Pfefferbaum et al.
Lin et al (the effect of Gadolinium on quantitative short echo time single voxel MRS of treated and untreated brain tumors) Proc. Intl. Soc. Mag. Med. 8 (2000).
Bernd Kuhn, Wolfgang Dreher, Dieter Leibfritz and Martin Heller; “Homonuclear Uncoupled 1H-Spectroscopy of the Human Brain Using Weighted Accumulation Schemes”; Magnetic Resonance Imaging, Tarrytown, NY, US, vol. 17, No. 8, pp. 1193-1201, 1999.
Netherlands Patent Office Search Report, Netherlands Patent Office, Application No. NL 1029000, Mar. 22, 2007.
Kantarci K, Xu Y, Shiung MM, O'Brien PC, Cha RH, Smith GE, Ivnik RJ, Boeve BF, Edland SD, Kokmen E and others. Comparative diagnostic utility of different MR modalities in mild cognitive impairment and Alzheimer's disease. Dement Geriatr Cogn Disord 2002; 14(4):198-207.
Krishnan KRR, Charles CC, Doraiswamy PM, Mintzer J, Weisler R, Yu X, Perdomo C, Ieni JR, Rogers S. Randomized, placebo-controlled trial of the effects of Donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease. Am J Psychiatry 2003; 160:2003-2011.
Hancu Ileana
Hurd Ralph Eugene
Sailasuta Napapon
Asmus Scott J.
Brutus Joel F
General Electric Company
Le Long V
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