Methods and systems for analysis and correction of mass...

Details Methods and systems for analysis and correction of mass... Methods and systems for analysis and correction of mass...

2011-07-19

2011-07-19

Wells, Nikita (Department: 2881)

Radiant energy

Ionic separation or analysis

C250S282000, C250S252100, C436S173000, C435S007100

Reexamination Certificate

active

07982180

ABSTRACT:
A background component of reporter ion signals is determined by fitting a distribution function. A plurality of samples that include a protein labeled with a plurality of isobaric reporter ions is analyzed at a plurality of different times using a mass spectrometer, producing a plurality of mass spectra for the plurality of isobaric reporter ions. A cumulative distribution is calculated for an inverse coefficient of differential expression of the plurality of mass spectra using a processor. A Pearson Type IV distribution shifted by a constant value is fitted to the cumulative distribution and the constant value is solved for using the processor. A background component for each spectrum of the plurality of mass spectra is calculated from the constant value, a calculated coefficient of differential expression for each spectrum, and an average reporter ion signal value for each spectrum using the processor.

REFERENCES:
patent: 7799576 (2010-09-01), Pappin et al.
patent: 2007/0218505 (2007-09-01), Kearney
patent: 2009/0065686 (2009-03-01), Shilov et al.

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