Methods and solutions for storing donor organs

Details Methods and solutions for storing donor organs Methods and solutions for storing donor organs

2006-04-18

2006-04-18

Saucier, Sandra E. (Department: 1651)

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

C435S001200, C435S001300

Reexamination Certificate

active

07029839

ABSTRACT:
A method of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation and washing solutions at least containing polyvinylpyrrolidone, a calcium channel blocker, a nucleoside, potassium chloride, polyethylene glycol, at least one amino acid, and a steroid to a temperature of 2° to 4° C. and/or of 0° to 2° C., harvesting a donor organ, perfusing it with one or more of the solution, immersing it in one or more of the solutions and storing it at a temperature above 0° C. or at a temperatures below 0° C. The cryopreservation solution also contains cryopreservative agents. Preserved organs may be transplanted directly from refrigeration storage or from freezer storage by cooling the washing refrigeration preservation solutions to 2° to 4° C., perfusing the organ with washing solution and then preservation solution, and transplanting it.

REFERENCES:
patent: 2662520 (1953-12-01), McMahon
patent: 2786014 (1957-03-01), Tullis
patent: 3579999 (1971-05-01), Schwartz
patent: 3729947 (1973-05-01), Higuchi
patent: 3753357 (1973-08-01), Schwartz
patent: 3841515 (1974-10-01), Schwartz
patent: 4059967 (1977-11-01), Rowe et al.
patent: 4473552 (1984-09-01), Jost
patent: 4559298 (1985-12-01), Fahy
patent: 4639373 (1987-01-01), Barbior
patent: 4695460 (1987-09-01), Holme
patent: 4764463 (1988-08-01), Mason et al.
patent: RE32874 (1989-02-01), Rock et al.
patent: 5328821 (1994-07-01), Fisher et al.
patent: 5474891 (1995-12-01), Murphy
patent: 5487971 (1996-01-01), Holme et al.
patent: 5554527 (1996-09-01), Fickensher
patent: 5622867 (1997-04-01), Livesay et al.
patent: 5635344 (1997-06-01), Garcia et al.
patent: 5827741 (1998-10-01), Beattie et al.
patent: 6080730 (2000-06-01), Lemasters et al.
patent: 6248363 (2001-06-01), Patel et al.
patent: 6740484 (2004-05-01), Khirabadi et al.
patent: 395432 (1924-06-01), None
patent: 2929278 (1981-01-01), None
patent: 0232672 (1990-07-01), None
patent: 2600671 (1987-12-01), None
patent: 1527655 (1978-10-01), None
patent: 04001135 (1992-01-01), None
patent: 1124974 (1984-11-01), None
patent: WO87/05468 (1987-09-01), None
patent: WO88/01871 (1988-03-01), None
patent: WO91/17655 (1991-11-01), None
patent: WO97/30350 (1997-08-01), None
patent: WO00/53008 (2000-09-01), None
Database WPI: Section CH, Week 198524 Derwent Publications Ltd., London, GB AN 1985-144847, XP002130628 & SU1124974A (AS SIBE BIOPHYS).
Broadthagen UA; et al. “Platelet cryopreservation with glycerol, dextran, and mannitol: recovery of 5-hydroxytryptamine uptake and hypotonic stress response” Cryo Biology, (Abstract) Feb. 1985, pp. 1-9, vol. 22.
Smillie JA, et al. “Cryopreservation of human platelets with polyvinylpyrrolidone” Transfusion (Abstract) 1981, pp552-556, vol. 21.
Sputtek A, et al. “Cryopreservation of human platelets with hydroxyethyl starch in a one-step procedure” Cryo Letters (Abstract) 1987, pp218-231, vol. 8.
Odink J; et al. Platelet preservation part 1 the Use of Decrease in Light Absorbance As a screening method in Cryo Preservation studies on Human Platelets , Cryo Biology 1977, pp 519-528, vol. 14 (abstract).
Fern Tablin, “Membrane Phase Transition of Intact Human Platelets: Correlation With Cold-Induced Activation”, Journal of Cellular Physiology, 1996, pp305-313, vol. 168.

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