Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2005-11-15
2005-11-15
Housel, James (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S007100, C435S007920, C424S185100, C424S186100, C424S233100
Reexamination Certificate
active
06964843
ABSTRACT:
The present invention provides methods and reagents for detecting antibodies to adenovirus. In a preferred embodiment, the present invention is useful for detecting antibodies to adenovirus serotype 5. In a further preferred embodiment, the present invention can be used in a biosensor-based assay. It is contemplated that the present invention is useful to detect antibodies for ascertaining adenovirus infection, evaluating patient response to gene therapy using adenovirus vectors, developing vaccines to adenovirus infection, developing therapeutics for inducing passive immunity to adenovirus infection, as well as other uses.
REFERENCES:
patent: 5424218 (1995-06-01), Miljanich et al.
Roder et al., “Biomolecular Interaction Analysis. Strategies for Antibody and Antigen Charaterization”, Methods In Molecular Medicine, vol. 13: Molecular Diagnosis of Infectious Diseases, pp. 531-554.
Zeng et al., “Analysis of Specific Interactions of Synthetic Glycopolypeptides Carrying N-Acetyllactosamine and Related Compounds with Lectins”, Carbohydrate Research 312 (1998) 209-217.
Karlsson et al., “Surface Plasmon Resonance Detection and Multispot Sensing for Direct Monitoring of Interactions Involving Low-Molecular-Weight Analytes and for Determination of Low Affinities”, Analytical Biochemistry 228 (1995) 274-280.
Wong et al., “Validation parameters for a novel biosensor assay which simultaneously measures serum concentrations of a humanized monoclonal antibody and detects induced antibodies”, Journal of Immunological Methods 209 (1997) 1-15.
Crawford-Miksza et al., “Analysis of 15 Adenovirus Hexon Proteins Reveals the Location and Structure of Seven Hypervariable Regions Containing Serotype-Specific Residues”, Journal of Virology 70:3 (Mar. 1996) 1836-1844.
Jonsson et al., “Introducing a biosensor based system for real-time biospecific interaction analysis”, Pharmacia Biosensor AB 1-9.
Toogood et al., “Antipeptide antisera define neutralizing epitopes on the adenovirus hexon”, Journal of General Virology 73 (1992) 1429-1435.
Kinloch et al., “Adenovirus Hexon. Sequence Comparison of Subgroup C serotypes 2 and 5”, The Journal of Biological Chemistry 259:10 (May 25, 1984) pp. 6431-4346.
Mytych Daniel T.
Swanson Steven J.
Connelly Nancy V.
Housel James
Li Bao Qun
Schering Corporation
Wyatt Donald W.
LandOfFree
Methods and reagents for the detection of antibodies to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and reagents for the detection of antibodies to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and reagents for the detection of antibodies to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3486626