Methods and reagents for oligonucleotide synthesis

Details Methods and reagents for oligonucleotide synthesis Methods and reagents for oligonucleotide synthesis

2007-04-17

2007-04-17

Lewis, Patrick (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S022100, C536S025310, C536S025320, C536S025330

Reexamination Certificate

active

10190359

ABSTRACT:
The present invention features novel compositions, linkers, derivatized solid supports, and methods for the efficient solid phase synthesis of oligonucleotides, including RNA, DNA, RNA-DNA chimeras, and analogs thereof.

REFERENCES:
patent: 4458066 (1984-07-01), Caruthers
patent: 4923901 (1990-05-01), Koester et al.
patent: 4973679 (1990-11-01), Caruthers
patent: 4987071 (1991-01-01), Cech et al.
patent: 5132418 (1992-07-01), Caruthers
patent: 5141813 (1992-08-01), Nelson
patent: 5153319 (1992-10-01), Caruthers
patent: 5218103 (1993-06-01), Caruthers et al.
patent: 5252723 (1993-10-01), Bhatt
patent: 5278302 (1994-01-01), Caruthers et al.
patent: 5281701 (1994-01-01), Vinayak
patent: 5334711 (1994-08-01), Sproat
patent: 5419966 (1995-05-01), Reed et al.
patent: 5525468 (1996-06-01), McSwiggen et al.
patent: 5589332 (1996-12-01), Shih et al.
patent: 5627053 (1997-05-01), Usman et al.
patent: 5672695 (1997-09-01), Eckstein et al.
patent: 5674856 (1997-10-01), Furukawa et al.
patent: 5686599 (1997-11-01), Tracz
patent: 5716824 (1998-02-01), Beigelman
patent: 5723599 (1998-03-01), Klem et al.
patent: 5741679 (1998-04-01), George et al.
patent: 5804683 (1998-09-01), Usman et al.
patent: 5831071 (1998-11-01), Wincott et al.
patent: 5834186 (1998-11-01), George et al.
patent: 5849902 (1998-12-01), Arrow et al.
patent: 5871914 (1999-02-01), Nathan et al.
patent: 5989912 (1999-11-01), Arrow et al.
patent: 280968 (1914-12-01), None
patent: 43 06 839 (1993-03-01), None
patent: 0 325 970 (1989-01-01), None
patent: 0 325 970 (1993-04-01), None
patent: 2 169 605 (1986-07-01), None
patent: WO 91/03162 (1991-03-01), None
patent: WO 92/07065 (1992-04-01), None
patent: WO 93/15187 (1993-08-01), None
patent: WO 93/23057 (1993-11-01), None
patent: WO 93/23569 (1993-11-01), None
patent: WO 94/01446 (1994-01-01), None
patent: WO 94/02595 (1994-02-01), None
patent: WO 59/04818 (1995-02-01), None
patent: WO 95/13380 (1995-05-01), None
patent: WO 95/23225 (1995-08-01), None
patent: WO 97/26270 (1997-07-01), None
patent: WO 97/42202 (1997-11-01), None
patent: WO 98/13526 (1998-04-01), None
patent: WO 98/27104 (1998-06-01), None
patent: WO 99/29842 (1999-06-01), None
patent: WO 99/54459 (1999-10-01), None
patent: WO 00/24931 (2000-05-01), None
patent: WO 00/26226 (2000-05-01), None
Alul et al., “Oxalyl-CPG: a labile support for synthesis of sensitive oligonucleotides derivatives,”Nucleic Acids Research19:1527-1532 (1991).
Bartel and Szostak, “Isolation of New Ribozymes from a Large Pool of Random Sequences,”Science261:1411 1418 (1993).
Bass, “The short answer,”Nature411:428-429 (2001).
Beaucage and Iyer, “The Functionalization of Oligonucleotides Via Phosphoramidite Derivatives,”Tetrahedron49:1925-1963 (1993).
Beaudry and Joyce, “Directed Evolution of an RNA Enzyme,” Science 257:635-641 (1992).
Beigelman et al., “Chemical Modification of Hammerhead Ribozymes,” J. Biol. Chem. 270:25702-25708 (1995.
Birch-Hirschfeld et al., “A versatile support for the synthesis of oligonucleotides of extended length and scale,”Nucleic Acids Research22:1760-1761 (1994).
Bonora et al., “Poly(N-acryloylmorpholine) As a New Soluble Support for the Liquid-Phase Synthesis of Oligonucleotides,”Tetrahedron Letters37:4761-4764 (1996).
Breaker and Joyce, “Inventing and improving ribozyme function: rational design versus iterative selection methods,” TIBTECH 12:268-275 (1994).
Brody and Gold, “Aptamers as therapeutic and diagnostic agents,”Reviews in Molecular Biotechnology74:5-13 (2000).
Burgin et al., “Chemically Modified Hammerhead Ribozymes with Improved Catalytic Rates,” Biochemistry 35:14090-14097 (1996).
Burlina et al., “Chemical Engineering of Rnase Resistant and Catalytically Active Hammerhead Ribozymes,”Bioorganic&Medicinal Chemistry5:1999-2010 (1997).
Caruthers et al., “Chemical Synthesis of Deoxyoligonucleotides and Deoxyoligonucleotide Analogs,”Methods i Enzymology211:3-19 (1992).
Cech, “Ribozymes and Their Medical Implications,”JAMA260:3030-3034 (1988).
Christoffersen and Marr, “Riobozymes as Human Therapeutic Agents,”J. Med. Chem.38:2023-2037 (1995).
Crooke, “Advances in Understanding the Pharmacological Properties of Antisense Oligonucleotides,”Advances in Pharmacology40:1-49 (1997).
Crooke, “Antisense Therapeutics,”Biotechnology and Genetic Engineering Reviews15:121-157 (1998).
Crooke, “Progress in Antisense Technology: The End of the Beginning,”Methods in Enzymology313:3-45 (1999).
Delihas et al., “Natural antisense RNA/target RNA interactions: Possible models for antisense oligonucleotide drug design,”Nature Biotechnology15:751-753 (1997).
Dell'Aquila et al., “Photolabile Linker for the Solid-Phase Synthesis of Base-Sensitive Oligonucleotides,”Tetrahedron Letters38(30):5289-5292 (1993).
Dreyfus, “Restriction Ribozymes?”Einstein Quarterly Journal of Biology and Medicine6:92-93 (1988).
Duval-Valentin, “Specific inhibition of transcription by triple helix-forming oligonucleotides,”Proc. Natl. Acad. Sci. USA89:504-508 (1992).
Earnshaw et al., “Modified Oligoribonucleotides as Site-Specific Probes of RNA Structure and Function,”Biopolymers48:39-55 (1998).
Egholm et al., “PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bondin rules,”Nature365:566-568 (1993).
Elbashir et al., “Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells,”,Nature411:494-498 (2001).
Fox, “Targeting DNA with Triplexes,”Current Medicinal Chemistry7:17-37 (2000).
Gait et al., “Ch. 2—Oligoribonucleotide synthesis,”Oligonucleotides and Analogues: A Practical Approacedited by Eckstein, IRL Press, Oxford, pp. 25-48 (1991).
Gold et al., Diversity of Oligonucleotide Functioins,Annu. Rev. Biochem.64:763-797 (1995).
Greenberg et al., “Photochemical Release of Protected Oligonucleotides Containing 3′-Glycolate Termini,”Tetrahedron51:29-38 (1995).
Hammann et al., “Length Variation of Helix III in a Hammerhead Ribozyme and Its Influence on Cleavage Activity,”Antisense&Nucleic Acid Drug Development9:25-31 (1999).
Hartmann et al., U.S. Appl. No. 60/101,174, filed Sep. 21, 1998 for “Hairpin Hybridizer Molecules for Modulation of Gene Expression.”
Haseloff and Gerlach, “Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities,”Nature334:585-591 (1988).
Hermann and Patel, “Adaptive Recignition by Nucleic Acid Aptamers,”Science287:820-825 (2000).
Hovinen et al., “Novel Solid Supports for the Preparation of 3′-Derivatized Oligonucleotides: Introduction of 3′ Alkylphosphate Tether Groups Bearing Amino, Carboxy, Carboxamido, and Mercapto Functionalities,”Tetrahedron50:7203-7218 (1994).
Hunziker et al., “Nucleic Acid Analogues: Synthesis and Properties, in Modern Synthetic Methods,”VCH, 331-417 (1995).
Jayasena, “Aptamers: An Emerging Class of Molecules that Rival Antibodies in Diagnostics,”Clinical Chemistr45:1628-1650 (1999).
Jeffries and Symons, “A Catalytic 13-mer Ribozyme,”Nucleic Acids Research17:1371-1377 (1989).
Joyce et al., “Amplification, mutation and selection of catalytic RNA,”Gene82:83-87 (1989).
Joyce, “Directed Molecular Evolution,” Scientific American 267:90-97 (1992).
Katzhendler et al., “The Effect of Spacer, Linkage and Solid Support on the Synthesis of Oligonucleotides,”Tetrahedron45:2777-2792 (1989).
Karpeisky et al, “Highly Efficient Synthesis of 2′-O-Amino Nucleosides And Their Incorporation in Hammerhead Ribozymes,”Tetrahedron Letters39:1131-1134 (1998).
Kim and Cech, “Three-dimensional model of the active site of the self-splicing rRNA precursor ofTetrahymena,&

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