Methods and reagents for lengthening telomeres

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Fused or hybrid cell – per se

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435 6, 435375, 536 231, C12N 510, C12N 512, C07H 2100, C07H 2107

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056863063

ABSTRACT:
Method and compositions for increasing telomere length in normal cells can be used to increase the proliferative capacity of cells and to delay the onset of cellular senescence.

REFERENCES:
patent: 4737454 (1988-04-01), Dattagupta et al.
patent: 5489508 (1996-02-01), West et al.
Gura, "Antisense has growing pains" Science 270:575-577, Oct. 1995.
Johnston et al. "Present status and future prospects for HIV therapies" Science 260:1286-1293, May 1993.
Milligan et al. "Current concepts in antisense drug design" J. Medicinal Chem. 36(14):1924-1937, Jul. 1993.
Tseng et al. "Antisense oligonucleotide technology in the development of cancer therapeutics" Cancer Gene Therapy 1(1):65-71, Mar. 1994.
Cotten, "The in vivo application of ribozymes," Trends in Biotechnology 8:174-178 (1990).
Counter et al., "Stabilization of Short Telomeres and Telomerase Activity Accompany Immortalization of Epstein-Barr Virus-Transformed Human B Lymphocytes," J. Virology 68:3410-3414 (1994).
Counter et al., "Telomerase activity in human ovarian carcinoma," Proc. Natl. Acad. Sci. USA 91:2900-2904 (1994).
Greider and Blackburn, "A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis," Nature 337:331-337 (1989).
Harley et al., "The Telomere Hypothesis of Cellular Aging," Expermiental Gerontology 27:375-382 (1992).
Shay et al., "Loss of telomeric DNA during aging may predipose cells to cancer (Review)," Int'l J. Oncology 3:559-563 (1993).
Strahl and Blackburn, "The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena," Nucleic Acids Research 22:893-900 (1994).
Windle and McGuire, "Telomeres: the long and the short of it," Proceedings of the American Association for Cancer Research 33:594-595 (1992).
Allsopp et al., "Telomere Length Predicts Replicative Capacity of Human Fibroblasts," Proc. Natl. Acad. Sci. USA 89:10114-10118 (1992).
Klingelhutz et al., "Restoration of Telomeres in Human Papoillomavirus-Immortalized Human Anogential Epithelial Cells," Molecular and Cellular Biology 14:961-969 (1994).
Grieder and Blackburn, "The Telomere Terminal Transferase of Tetrahymena Is a Ribonucleoprotein Enzyme with Two kinds of Primer Specificity", 51 Cell 887, 1987.
Blackburn et al., "Recognition and elongation of telomeres by telomerase", 31 Genome 553, 1989.
Greider, "Telomerase Is Processive", 11 Molec. and Cell. Biology 4572, 1991.
Counter et al., "Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity", 11 EMBO 1921, 1992.
Harley, "Telomere loss: mitotic clock or genetic time bomb?", 256 Mutation Res. 271, 1991.
Eck and Nabel, "Antisense oligonucleotides for therapeutic intervention", 2, Opin. Biotech 897, 1991.
Zahler et al., "Inhibition of telomerase by G-quartet DNA structures", 350 Nature, 718, 1991.
Yu and Blackburn, "Developmentally Programmed Healing of Chromosomes by Telomerase in Tetrahymena", 67 Cell 823, 1991.
Harley et al., "Telomeres shorten during ageing of human fibroblasts", 345 Nature 458, 1990.
Blackburn, "Structure and function of telomeres", 350 Nature 569, 1991.
Cech, "Ribozymes and Their Medical Implications", 260 JAMA 3030, 1988.
S. Wang and V. Zakian (1990) Nature 345:456. Telomere-telomere recombination provides an express pathway for telomere acquisition.
S. Goldstein (1990) Science 249:1129. Replicative senescence: the human fibroblast comes of age.
J. Smith and R. Whitriey (1980) Science 207:82. Intracional variation in proliferative potential of human diploid fibroblasts:stochastic mechanisms for cellular aging.
T. Ohno (1979) Mechanisms of aging and development 11:179. Strict relationship between dialyzed serum concentration and cellular life span in vitro.
L. Hayflick and P. Moorhead (1961) Experimental Cell Research 25:585. The serial cultivation of human diploid cell strains.
J. Szostak (1989) Nature 337:303. The beginning of the ends.
G. Jankovic, et al. (1991) Nature 350:197. Telomere loss and cancer.
J. Gall (1990) Nature 344:108. Typing up loose ends.
G. Yu, et al. (1990) Nature 344:126. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.
L. Harrington and C. Greider (1991) Nature 353:451. Telomerase primer specificity and chromosome healing.
J. Gray, et al. (1991) Cell 67:807. Cloning and expression of genes for the Oxytricha telomere-binding protein:specific subunit interactions in the telomeric complex.
F. Muller, et al. (1991) Cell 67:815. New telomere formation after developmentally regulated chromosomal breakage during the process of chromosome diminution in Ascarls lumbricoides.
C. Greider (1990) Bloessays 12:363. Telomers, telomerase and senesence.
E. Henderson, et al. (1990) Biochemistry 29:732. Telomere G-strand structure and function analyzed by chemical protection, base analogue substitution, and utilization by telomerase in vitro.
D. Gottschling, et al. (1990) Cell 63:751. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.
V. Lundblad and J. Szostak (1989) Cell 57:633. A mutant with a defect in telomere elongation leads to senescence in yeast.
E. Blackburn (1984) Annual Reviews in Biochemistry 53:163. The molecular structure of centromeres and telomeres.
A. Olovnikov (1973) J. Theoretical Biology 41:181. A theory of marginotomy.
H. Cooke and B. Smith (1986) CSHSQB LI:213. Variability at the telomeres of the human X/Y pseudoautosomal region.
C. Greider (1991) Cell 67:645. Chromosome first aid.
G. Morin (1989) Cell 59:521. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats.
C. Harley, et al. (1990) Nature 345:458. Telomeres shorten during ageing of human fibroblasts.
Ham and McKeehan (1979) Methods in Enzymology LVIII:44. Media and growth requirements.
J. Starling, et al. (1990) Nucleic Acids Research 18:6881. Extensive telomere repeat arrays in mouse are hypervariable.

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