Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-06-06
1997-07-01
Campbell, Eggerton A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, C12Q 168, C12P 1934
Patent
active
056437242
ABSTRACT:
Methods and reagents for determining an individual's genotype at the Glycophorin A locus with respect to a set of five alleles using sequence-specific oligonucleotide probes enable one to type samples from a variety of sources, including samples comprising RNA or cDNA templates, and can be applied to nucleic acids in which a target region spanning the polymorphism has been amplified. This typing facilitates typing tissue for determining individual identity and has application in the field of forensic science.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
Furthmayr, Feb., 1978, "Structural Comparison of Glycophorins and Immunochemical Analysis of Genetic Variants" Nature 271:519-524.
Siebert and Fukuda, Oct., 1987, "Molecular Cloning of a Human Glycophorin B cDNA: Nucleotide Sequence and Genomic Relationship to Glycophorin A" Proc. Natl. Acad. Sci. USA 84:6735-6739.
Kudo and Fukuda, Jun., 1989, "Structural Organization of Glycophorin A and B Genes: Glycophorin B Gene Evolved by Homologous Recombination at Alu Repeat Sequences" Proc. Natl. Acad. Sci. USA 86:4619-4623.
Fildes et al., 1994, American Academy Forensic Sciences (46th Annual Meeting) p. 97, Abstract No. B110 "Discovery of a New GYPA Allele in the U.S. African American Population".
Huang et al J. Biol. Chem 267:3336-3342 (1992).
Fildes Nicola Jane
Reynolds Rebecca Lynne
Campbell Eggerton A.
Johnston George W.
Petry Douglas A.
Roche Molecular Systems Inc.
Sias Stacey R.
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