Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-11-13
2007-11-13
Prouty, Rebecca E. (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S069100, C435S320100, C435S325000, C536S023500
Reexamination Certificate
active
11591992
ABSTRACT:
The invention relates to methods and reagents for diagnosing and treating diabetes.
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patent: WO 02/034934 (2002-05-01), None
patent: WO 02/074326 (2002-09-01), None
Sequence alignment of SEQ ID No. 2.
Barroso, “Dominant negative mutations in human PPARy associated with severe insulin resistance, diabetes mellitus and hypertension”,Nature, 1999, pp. 880-883, vol. 402.
Hsu, et al., “Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor”,Nature Medicine, 2001, pp. 605-611, vol. 7(5).
Hu, et al., “Inhibition ofAdipogenesisThrough MAP Kinase-Mediated Phosphorylation of PPARy”,Science, 1996, pp. 2100-2103, vol. 274.
Lewis, et al., “Identification of urocortin III, an additional member of the corticotrophin-releasing factor (CRF) family with high affinity for the CRF2 receptor”,Proceedings of the National Academy of Sciences USA, Jun. 19, 2001, pp. 7570-7575, vol. 98(13).
Blume John E.
Johnson Jeffrey D
Palma John F.
Zhou Yun-Ping
Chowdhury Iqbal
Metabolex Inc.
Prouty Rebecca E.
Townsend and Townsend / and Crew LLP
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