Methods and reagents for diagnosis and treatment of diabetes

Details Methods and reagents for diagnosis and treatment of diabetes Methods and reagents for diagnosis and treatment of diabetes

2006-12-05

2006-12-05

Achutamurthy, Ponnathapu (Department: 1652)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C514S012200, C514S435000, C514S007100, C514S003100, C514S320000, C435S325000, C435S069100, C424S146100, C424S078310, C530S388850

Reexamination Certificate

active

07144985

ABSTRACT:
The invention relates to methods of determining islet cell activity by detecting the level of Archipelin or a fragment thereof and comparing the level to a baseline level or range associated with a known islet cell activity. Such methods are useful in diagnosing and studying the development of diabetes.

REFERENCES:
patent: 2002/0082409 (2002-06-01), Hsu et al.
patent: 2003/0036507 (2003-02-01), Vale et al.
patent: WO 02/34934 (2002-05-01), None
patent: WO 02/74326 (2002-09-01), None
Lewis et al. GenBank Accession No. AAK67317, “Homo sapiensurocortin III (UCNIII) gene, complete cds”, Jun. 27, 2001.
Hsu et al.,Nature Medicine, 7:5: 605-611 (2001).
Lewis et al.,PNAS, 98:13: 7570-7575 (2001).
Barroso et al.,Nature23/30:402: 880-883 (1999).
Hu et al.,Science274: 2100-2103 (1996).

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