Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-09
2006-05-09
Saunders, David (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S013000, C435S810000, C435S975000, C436S501000, C436S518000, C436S808000, C436S809000, C436S821000
Reexamination Certificate
active
07041458
ABSTRACT:
The present invention relates to an assay for free protein S comprising the addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and subsequent determination of the amount of the complex formed in the sample. The ligand specific for free protein S is comprised of the C4b binding protein (C4BP), or part thereof, or a compound comprising an amino acid residue sequence that binds specifically to the binding site for C4BP in protein S. The present invention further relates to antibodies specific for free protein S, which can be used as ligands in the assay of the invention, and with protein S related polypeptides, which can be used to produce such antibodies. In addition, the present invention is related to diagnostic test systems, suitable in kit form, comprising the present ligand and at least one further reagent required in the assay for free protein S.
REFERENCES:
patent: 4184849 (1980-01-01), Cambiaso et al.
patent: 4210723 (1980-07-01), Dorman et al.
patent: 4401765 (1983-08-01), Craig et al.
patent: 4480042 (1984-10-01), Craig et al.
patent: 4622389 (1986-11-01), Nagasawa et al.
patent: 4692406 (1987-09-01), Becker et al.
patent: 4755461 (1988-07-01), Lawson et al.
patent: 4843021 (1989-06-01), Noguchi et al.
patent: 4849403 (1989-07-01), Stocker et al.
patent: 5001069 (1991-03-01), Bartl et al.
patent: 5051357 (1991-09-01), Hassouna
patent: 5059525 (1991-10-01), Bartl et al.
patent: 5095097 (1992-03-01), Hermentin et al.
patent: 5147805 (1992-09-01), Preda et al.
patent: 5169786 (1992-12-01), Carroll et al.
patent: 5187067 (1993-02-01), Koike et al.
patent: 5200322 (1993-04-01), Matsumoto
patent: 5223427 (1993-06-01), Edgington et al.
patent: 5254350 (1993-10-01), Barrow et al.
patent: 5270451 (1993-12-01), Hawkins et al.
patent: 5308756 (1994-05-01), van de Waart et al.
patent: 5314695 (1994-05-01), Brown
patent: 5358853 (1994-10-01), Butler et al.
patent: 5374617 (1994-12-01), Morrissey et al.
patent: 5391380 (1995-02-01), Barrow et al.
patent: 5405946 (1995-04-01), Griffin et al.
patent: 5418141 (1995-05-01), Zweig et al.
patent: 5426031 (1995-06-01), Hawkins et al.
patent: 5439802 (1995-08-01), Rosén
patent: 5443960 (1995-08-01), Dahlbäck
patent: 5472850 (1995-12-01), Morrissey
patent: 5502651 (1996-03-01), Jackson et al.
patent: 5504064 (1996-04-01), Morrissey et al.
patent: 5504067 (1996-04-01), Morrissey et al.
patent: 5506112 (1996-04-01), Lang et al.
patent: 5508170 (1996-04-01), Butler et al.
patent: 5525478 (1996-06-01), Matschiner
patent: 5585278 (1996-12-01), Vunnam et al.
patent: 5597700 (1997-01-01), Konstantinov et al.
patent: 5643739 (1997-07-01), Varadi et al.
patent: 5705395 (1998-01-01), Griffin et al.
patent: 5716795 (1998-02-01), Matschiner
patent: 5726028 (1998-03-01), Kraus
patent: 5741658 (1998-04-01), Morrissey et al.
patent: 5753510 (1998-05-01), Kraus
patent: 5766869 (1998-06-01), Arkel et al.
patent: 5780255 (1998-07-01), Preda
patent: 5834223 (1998-11-01), Griffin et al.
patent: 5858648 (1999-01-01), Steel et al.
patent: 5858724 (1999-01-01), Novy, Jr. et al.
patent: 5874256 (1999-02-01), Bertina et al.
patent: 6083757 (2000-07-01), Griffin et al.
patent: 6124430 (2000-09-01), Mischak et al.
patent: 6203816 (2001-03-01), Brown
patent: 0 229 234 (1987-07-01), None
patent: 0 271 810 (1988-06-01), None
patent: 0476545 (1992-03-01), None
patent: 0 286 323 (1993-12-01), None
patent: 0 434 377 (1995-08-01), None
patent: 0944837 (2004-12-01), None
patent: 88/07543 (1988-10-01), None
patent: 90/11368 (1990-10-01), None
patent: 91/01382 (1991-02-01), None
patent: 91/01383 (1991-02-01), None
patent: 91/02812 (1991-03-01), None
patent: 92/08479 (1992-05-01), None
patent: 93/01209 (1993-01-01), None
patent: 93/07492 (1993-04-01), None
patent: 93/10261 (1993-05-01), None
patent: 93/13211 (1993-07-01), None
patent: 93/23074 (1993-11-01), None
patent: 95/21938 (1995-08-01), None
patent: 98/23963 (1998-06-01), None
Hillarp et al, Jour, of Biological Chemistry, 263, 12759-12764, 1988.
Amer et al. “Impairment of the Protein C Anticoagulant Pathway in a Patient with Systemic Lupus Erythematosus, Anticardiolipin Antibodies and Thrombosis,”Thrombosis Research,57:247-258 (1990).
Amiral et al. “New Direct Assay of Free Protein S Antigen Using Two Distinct Monoclonal Antibodies Specific for the Free Form,”Blood Coag. Fibrin.,5:179-186 (1994).
“Antigen-Antibody Crossed Electrophoresis,”Analytical Biochemistry,10(2):358-361 (1965).
Andrews et al. “Conservation of Tissue Factor Primary Sequence Among Three Mammalian Species,”Gene,98:265-269 (1991).
Bader et al. “Multicentric Evaluation of a New PT Reagent Based on Recombinant Human Tissue Factor and Synthetic Phospholipids,”Thromb. Haemost.,71(3):292-299 (1994).
Baele et al. “Comparison of a Recombinant Thromboplastin with Thrombotest™ for Oral Anticoagulant Control,”Haemost.,26:11-15 (1996).
Bauer “Hypercoaguability—A New Cofactor in the Protein C Anticoagulant Pathway,”New England Journal of Medicine,330:566-567 (1994).
Beauchamp et al. “High Prevalence of a Mutation in the Factor V Gene Within the U.K. Population: Relationship to Activated Protein C Resistance and Familial Thrombosis,”British J. of Haemost.,88:219-222 (1994).
Beck et al. “Protein C: ein Inhibitor der Blutgerinnung,”Diagnose & Labor,38:35-42 (Abstract in English) (1988).
Bertina “Specificity of Protein C and Protein S Assays,”Res. Clin. Lab.,20:127-138 (1990).
Bertina et al. “Mutation in Blood Coagulation Factor V Associated with Resistance to Activated Protein C,”Nature,369:64-67 (1994).
Bertina et al. “Determination of Plasma Protein S—The Protein Cofactor of Activated Protein C,”Thrombosis Haemostasis,53:268-272 (1985).
Blangero et al. “Normal Activated Protein C Response has a Large Genetic Component,”Florencia,PS-920, p. 226 (Jun. 9, 1997).
Blangero et al. “Genetic Factors Influence Quantitative Variation in Tissue Factor Pathway Inhibitor,”Florencia,PS-1666, p. 409 (1997).
Blombäck et al. “Chromogenic Peptide Substrates in the Laboratory Diagnosis of Clotting Disorders,”Haemostasis and Thrombosis,Bloom and Thomas (eds.), 2nded, 967-981 (1987).
Boyer-Neumann et al. “Comparison of Functional Assays for Protein S: European Collaborative Study of Patients with Congenital and Acquired Deficiency,”Thomb. and Haemost.,70(6):946-950 (1993).
Chromogenix, Coatest APC Resistance Kit Brochure, Jun. 1993.
Comp “Laboratory Evaluation of Protein S Status,”Seminars in Thromb. and Haemost.,16(2):177-181 (1990).
Comp et al. “An Abnormal Plasma Distribution of Protein S Occurs in Functional Protein S Deficiency”Blood,67(2):504-508 (1986).
Cornillon et al. “Rat Coagulation Factor V Purification and Production of the Monospecific Antiserum,”Comp. Biochem. Physiol.,83B, 2: 397-401 (1986).
“Correlation of the APC Ratio with Free Protein S Antigen and with Protein C Activity” Appendix 5, 3 pages (Publication date not known).
Cripe et al. “Structure of the Gene for Human Coagulation Factor V,”Biochemistry,31: 3777-3785 (1992).
Dahlbäck “Protein S and C4b-Binding Protein: Components Involved in the Regulation of the Protein C Anticoagulant System”Thromb. Haemost.,66(1):49-61 (1991).
Dahlbäck et al. “Primary Structure of Bovine Vitamin K-Dependent Protein S”Proc. Natl. Acad. Sci.,83:4199-4203 (1986).
Dahlbäck et al. “Characterization of Functionally Important Domains in Human Vitamin K-Dependent Protein S Using Monoclonal Antibodies”J. Biol. Chem.,265(14):8127-8135 (1990).
Dahlbäck, et al. “The Protein C Anticoagulant System”The Molecular Basis of Blood Disease,W.B. Saunders Company, Philadelphia, PA, 599-627 (1994).
Dahlbäck et al. “Resistance to Activated Protein C, the FV:Q506Allele, and Venou
Kirkpatrick & Lockhart Nicholson & Graham LLP
Saunders David
T.A.C. Thrombosis and Coagulation Aktiebolag
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