Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2003-01-14
2009-12-22
Falk, Anne-Marie (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100
Reexamination Certificate
active
07635768
ABSTRACT:
A recombinant nucleic acid comprising nucleotides corresponding to a 3.2 kb 3′ untranslated region present in mouse calcium calmodulin kinase II alpha subunit-encoding mRNA is provided. An isolated nucleic acid which hybridizes to the 3′ untranslated region of mouse calcium calmodulin kinase II alpha subunit-encoding mRNA under conditions comprising two post-hybridization washes of 15 minutes each at 42° C. in 0.2× standard sodium citrate buffer is also provided.
REFERENCES:
patent: 5814500 (1998-09-01), Dietz
patent: 6509190 (2003-01-01), Kandel et al.
patent: WO9746257 (1997-12-01), None
patent: WO9924457 (1999-05-01), None
patent: WO0009662 (2000-02-01), None
Bej et al. (1991) Detection of coliform bacteria andEscherichia coliby multiplex polymerase chain reaction: Comparison with defined substrate and plating methods for water quality monitoring. Applied and Environmental Microbiology 57(8): 2429-2432.
Abel, T., et al., (1997) Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88: 625-626.
Bach, M., et al., (1995) Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the ⊖ frequency. Cell 81: 905-915.
Chen, J. and Kelly P.T., (1996) Retinoic acid stimulates—CaMKII gene expression in PC12 cells at a distinct transcription initiation site. J. of Neuroscience 16(18): 5704-5714.
Kojima, N., et al., (1997) Rescuing impairment of long-term potentiation in fyn-deficient mice By introducing fyn transgene. Proc. Natl. Acad. Sci. 94: 4761-4765.
Mayford, M., et al., (1995) Transgenic approaches to cognition. Current Opin. Neurobiol. 5: 141-148.
Mayford, M., et al., (1995) CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell 81: 891-904.
Mayford, M., et al., (1996) Control of memory formation through regulated expression of a CaMKII transgene. Science 274: 1678-1683.
Mayford, M., et al., (1996) CaMKII function in the nervous system explored from a genetic perspective. Cold Spring Harbor Lab. Press 59: 219-214.
Mayford, M., et al., (1996) The 3′ -untranslated region of CaMKIIα is a cis-acting signal for the localization and translation of mRNA in dendrites. Proc. Natl. Acad. Sci. U. S. A. 93: 13250-13255.
Mayford, M. et al., (1997) Memory and behavior: a second generation of genetically modified mice. Current Biol. 7: R580-R589.
McHugh, T., et al., (1996) Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87: 1339-1349.
Olson, N.J., et al., (1995) Functional identification of the promoter for the gene encoding the subunit of calcium/calmodulin-dependent protein kinase II. Proc. Natl. Acad. Sci. U.S.A. 92: 1659-1663.
Roush, W., (1997) New knockout mice point to molecular basis of memory. Science 275: 32-33.
Sunyer, et al, (1990) Sequence analysis and DNA-protein interactions within the 5′ flanking region of the calcium ion alpha-subunit gene. Proc. Natl. Acad. Sci. U.S.A. 87:278-282.
Tsien, J., et al., (1996) Subregion- and cell type-restricted gene knockout in mouse brain. Cell 87: 1317-1326.
Winder et al., (1998) Genetic and Pharmacological evidence for a novel,intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92:25-37.
European Search Report dated Apr. 3, 2002 issued in connection with PCT/US98/24157.
European Search Report (Partial) issued in connection with PCT/US99/18860 on Aug. 16, 2002.
European Search Report (Incomplete) issued in connection with PCT/US99/18860 on Jan. 24, 2003.
PCT International Search Report dated Feb. 24, 1999, issued in connection with International Application No. PCT/US98/24157.
PCT International Search Report dated Nov. 27, 2000, issued in connection with International Application No. PCT/US99/18860.
PCT Written Opinion dated Jun. 29, 2000, issued in connection with International Application No. PCT/US99/18860.
Alvarez, P. et al. (1994) “The animal model of human amnesia: Long-term memory impaired and short-term memory intact.” Proc. Natl. Acad. Sci. USA. 51:5637-5641.
Baier, G. et al. (1994) “Construction and characterization of lck- and fyn-specific tRNA: ribozyme chimeras.” Mol. Immunol. 31(12):923-32.
Bartsch., D. et al. (1995) “Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change.” Cell 83:979-992.
Bear, M.F., and Abraham, W.C. (1996) “Long-term depression in hippocampus.” Ann. Rev. Neurosci. 19:437-462.
Bennett, P.C. et al. (1996) “Cyclosporin A, an inhibitor of calcineurin, impairs memory formation in day-old chicks.” Brain Res. 730:107-117.
Bito, H. et al. (1996) “CREB phosphorylation and dephosphorylation: A calcium- and stimulus duration-dependent switch for hippocampal gene expression.” Cell 87:1203-1214.
Blichenberg A. et al. (2001) “Identification of a cis-acting dendritic targeting element in the mRNA encoding the alpha subunit of Ca2+/calmodulin-dependent protein kinase II.” Eur. J. Neurosci. (13):1881-8.
Bliss, T.V.P., and Collingridge, G. (1993) “A synaptic model of memory: long-term potentiation in the hippocampus.” Nature 361:31-39.
Blitzer, R.D. et al. (1995) “Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region.” Neuron 15:1403-1414.
Bolshakov V.Y. et al. “Recruitment of new sites of synaptic transmission during the cAMP-dependent late phase of LTP at CA3-CA1 synapses in the hippocampus.” Neuron Sep. 1997;19(3):635-51.
Cummings, J.A. et al. (1996) “Calcium signaling requirements for long-term depression in the hippocampus.” Neuron 16:825-833.
Figurov, A. et al. (1993) “Enhancement of AMPA-mediated synaptic transmission by the protein phosphatase inhibitor calyculin A in rat hippocampal slices.” Eur. J. Neurosci. 5:1035-1041.
Good, P.D. et al. (1997) “Expression of small, therapeutic RNAs in human cell nuclei.” Gene Ther. 4(1):45-54.
Gossen, M. et al. (1995) “Transcriptional activation by tetracyclines in mammalian cells.” Science 268:1766-1769.
Huang, Y.Y. and Kandel, E. R. (1994) “Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.” Learn. Mem. 1:74-82.
Huang, Y.Y. et al. (1996) “Long-lasting forms of synaptic potentiation in the mammalian hippocampus.” Learn. Mem. 3:74-85.
Ikegami S. et al. (1996) “A facilitatory effect on the induction of long-term potentiation in vivo by chronic administration of antisense oligodeoxynucleotides against catalytic subunits of calcineurin.” Brain Res. Mol. Brain Res. Sep. 5;41(1-2):183-91.
Kindler S. and Monshausen M. (2002) “Candidate RNA-binding proteins regulating extrasomatic mRNA targeting and translation in mammalian neurons.” Mol. Neurobiol. (2):149-65.
Krichevsky A.M., and Kosik K.S. (2001) “Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation.” Neuron 32(4):683-96.
Kuno, T. et al. (1992) “Distinct cellular expression of calcineurin Aα and Aβ in rat brain.” J. Neurochem. 58:1643-1651.
Lisman, J. (1994) “The CaM kinase II hypothesis for the storage of synaptic memory.” Trends Neurosci. 17:406-412.
Lu, Y. F. et al. (1996) “Calcineurin inhibitors, FK506 and cyclosporin A, suppress the NMDA receptor-mediated potentials and LTP, but not depotentiation in the rat hippocampus.” Brain Res. 729:142-146.
Malenka, R.C., and Nicoll, R.A. (1993) “NMDA receptor-dependent synaptic plasticity: multiple forms and mechanisms.” Trends Neurosci. 16:521-527.
Mansuy, I. et al. (1998) “Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.&#
Kandel Eric R.
Mayford Mark
Cooper & Dunham LLP
Falk Anne-Marie
The Trustees of Columbia University in the City of New York
White John P.
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