Methods and products related to 16-HETE analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Reexamination Certificate

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C554S213000, C554S219000, C554S224000

Reexamination Certificate

active

06903135

ABSTRACT:
The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from, thromboembolic stroke.

REFERENCES:
patent: 5164381 (1992-11-01), Wachter et al.
patent: 5256538 (1993-10-01), Aiken et al.
patent: 5334736 (1994-08-01), Sun et al.
patent: 5434186 (1995-07-01), Cohen et al.
patent: 5466669 (1995-11-01), Konig et al.
patent: 5527890 (1996-06-01), Rao et al.
patent: 5552441 (1996-09-01), Dillard et al.
patent: 5612377 (1997-03-01), Crooks et al.
patent: 5753702 (1998-05-01), Bednar et al.
patent: 6359158 (2002-03-01), Falck et al.
patent: 6562988 (2003-05-01), Falck et al.
patent: WO 97/44024 (1997-11-01), None
patent: WO 03/024922 (2003-03-01), None
Balazy, M., “Metabolism of 5,6-Epoxyeicosatrienoic Acid by the Human Platelet, Formation of Novel Thromboxane Analogs”,The Journal of Biological Chemistry, December 15, 1991, pp. 23561-23567, vol. 266, No. 35, The American Society of Biochemistry and Molecular Biology, Inc. USA.
Bednar, M.M. et al., “16-HETE: A Novel Arachidonate Metabolite Which Inhibits Human Leukocyte Function”, Jun. 1994, Abstract, Meeting in Florence, Italy.
Bednar, M.M. et al., “Neutrophil and Platelet Activity and Quantification Following Delayed tPA Therapy in a Rabbit Model of Thromboembolic Stroke”,Journal of Thrombosis and Thrombolysis, 1995, pp. 179-185, vol. 1, Kluwer Academic Publishers, Boston, Printed: Netherlands.
Dan, J. et al., “Constituent acids of Cucumis sativus fruit cutin”,Asian J. Chem., 1995, pp. 381-388, vol. 7, No. 2, Abstract 1995:515704, 123:29628.
Falck, J.R. et al., “Cytochrome P-450-dependent Oxidation of Arachidonic Acid to 16-, 17-, and 18-Hydroxyeicosatetraenoic Acids”,The Journal of Biological Chemistry, Jun. 25, 1990, pp. 10244-10249, vol. 265, No. 18, The American Society of Biochemistry and Molecular Biology, Inc. USA.
Gross, C.E. et al., “TGF-β1 post-treatment in a rabbit model ofcerbral ischaemia”, Neurological Research, Dec. 1994, pp. 465-470, vol. 16, Forefront Publishing Group.
Hatzelmann, A. et al., “The ω-hydroxylation of arachidonic acid by human polymorphonuclear leukocytes”,Eur. J. Biochem., 1988, pp. 445-452, vol. 173, FEBS.
Heckmann, B. et al., “Chiral Acetals: Stereocontrolled Syntheses of 16-, 17-, and 18-Hydroxyeicosatetraenoic Acids, Cytochrome P-450 Arachidonate Metabolites”,Tetrahedron Letters, 1996, pp. 1425-1428, vol. 37, No. 9, Elsevier Science Ltd. Great Britain.
Hill, E. et al., “Quantitation of 20-Hydroxy-5,8,11,14-eicosatetraenoic Acid (20-HETE) Produced by Human Polymorphonuclear Leukocytes Using Electron Capture Ionization Gas Chromatography/Mass Spectrometry”,Biological Mass Spectrometry, 1992, pp. 249-253, vol. 21, John Wiley & Sons Ltd.
Knickle, L.C. et al., “Bioactivation of arachiodonic acid by the cytochrome P450 monooxygenases of guinea pig lung: the ortholog of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids”,Mol. Pharmacol, 1994, pp. 1273-1280, vol. 45, No. 6, Abstract 1994:474474 121:74474.
Kraemer, R. et al., “A Neutrophil-Derived Cytochrome P450-Dependent Metabolite of Arachidonic Acid Modulates Neutrophil Behavior”,American Journal of Pathology, Sep. 1987, pp. 446-454, vol. 128, No. 3, American Association of Pathologists.
Laethem, R.M. et al., “Formation of 19(S)-, 19(R)-, and 18(R)-Hydroxyeicosatetraenoic Acids by Alcohol-inducible Cytochrome P450 2EI”,The Journal of Biological Chemistry, Jun. 15, 1993, pp. 12912-12918, vol. 268, No. 17, The American Society for Biochemistry and Molecular Biology, Inc. USA.
Lee, T.H. et al., “Effect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on In Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function”,The New England Journal of Medicine, May 9, 1985, pp. 1217-1224, vol. 312, No. 19.
Lesch, M.E. et al., “The effects of (R)-N-(1-methyl-2-phenylethyl) adenosine (L-PIA), a standard A1-selective adenosine agonist on rat acute models of inflammation and neutrophil function”,Agents and Actions, 1991, pp. 25-27, vol. 34, No. 1/2, Birkauser Verlag, Basel.
Setty, B.N. et al., “15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers—sn-1,2-diacylglycerol and inositol-1,4,5,-trisphosphate”,Blood, Dec. 1, 1992, pp. 2765-2773, vol. 80, No. 11, Abstract 93081777.
Springer, T.A., “The Sensation and Regulation of Interactions with the Extracellular Environment: The Cell Biology of Lymphocyte Adhesion Receptors”,Annu. Rev. Cell. Biol., 1990, pp. 359-402, vol. 6, Annual Reviews, Inc.
Subbaraman, A.S. et al., “A facile racemic synthesis of eicosane-1, 16-diol, an aglycone of a marine natural product forbesin”,Indian J. Chem., 1992, pp. 262-263, vol. 31B, No. 4, Sect. B, Abstract 1992:214224 116:214224.
Takata, S. et al., “15-Hydroxyeicosatetraenoic acid inhibits neutrophil migration across cytokine-activated endothelium”,Am J. Pathol., 1994, pp. 541-549, vol. 145, No. 3, Abstract 1995:138771 122:29618.
Watanabe, M. et al., “Stimulation of neutrophil adherence to vascular endothelial cells by histamine and thrombin and its inhibition by PAF antagonists and dexamethasone”,Br. J. Pharmacol., 1991, pp. 239-245, vol. 102, Macmillan Press Ltd.
Zeldin, L.G. et al., “Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid”,Archives of Biochemistry & Biophysics, Sep. 1, 1998, pp. 45-57, vol. 357, No. 1, Abstract 98389577.
Zhu, Y. et al., “Identification of Arachidonate P-450 Metabolites in Human Platelet Phospholipids”,Hypertension, Apr. 1995, pp. 854-859, vol. 25, No. 4, Part 2.

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